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Mechanisms involved in the poor prognosis of cirrhosis (favoring the occurrence of multiorgan failures) and their related markers. Systemic inflammation and endothelial dysfunction appear as high relevant factors not reflected by Child-Pugh, MELD score, or measure of the HVPG. They worsen liver function, increase portal hypertension, and self-sustain the processes. HVPG: Hepatic venous pressure gradient; CRP: C-reactive protein; ADAMTS13: A metalloprotease with decreased activity.
