Table 2.
Blood Oxygen Level Dependent Responses to Rewarding (Chocolate) Stimuli and Aversive Strawberry THCv vs Placebo
| Anatomical region | Coordinates (MNI) | Z-score | P | ||
|---|---|---|---|---|---|
| X | Y | Z | |||
| Chocolate sight | |||||
| Putamen | 16 | 10 | −6 | 2.74 | .03 svc |
| ACC | −2 | 20 | 36 | 3.19 | .03 svc |
| Caudate | −8 | 8 | 18 | 4.09 | <.001 |
| Mid brain | 6 | −6 | −2 | 3.95 | <.001 |
| Cingulate gyrus | −18 | −28 | 36 | 3.8 | <.001 |
| Chocolate sight and taste | |||||
| Mid cingulate gyrus | −14 | −8 | 42 | 3.5 | <.001 |
| Strawberry sight | |||||
| Insula | 38 | 10 | 10 | 3.46 | <.001 |
| Mid OFC | −16 | 36 | −10 | 3.42 | <.001 |
| STG | 54 | 10 | −10 | 3.43 | <.001 |
| Putamen | −26 | 8 | −12 | 3.3 | <.001 |
| Strawberry sight and taste | |||||
| Putamen | 16 | 6 | −2 | 2.74 | .03 svc |
| Amygdala | 24 | 6 | −18 | 2.66 | .03 svc |
| Insula | −38 | 14 | −14 | 2.98 | .005 |
| Mid OFC | −18 | 32 | −10 | 3.28 | .005 |
| STG | 54 | 10 | −10 | 3.81 | .005 |
| Thalamus | 4 | −6 | 6 | 3.23 | .005 |
| Caudate | −8 | 14 | 2 | 3.09 | .005 |
Abbreviations: ACC, anterior cingulate cortex; FWE, family wise error; MNI, Montreal Neurological Institute; OFC, orbitofrontal cortex; STG, superior temporal gyrus; svc, small volume corrected; tetrahydrocannabivarin, THCv.
Threshold set at P<.05. P-values: svc (P<.05 FWE-corrected for multiple comparisons). P values: whole brain corrected (P<.05 FWE-corrected for multiple comparisons). Gender and order were added as covariates of no interest.