Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jan 29;18(6):pyu102. doi: 10.1093/ijnp/pyu102

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Published by Oxford University Press on behalf of CINP 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.

PMC Copyright notice

Figure 4. — Preketamine treatment with a low therapeutic dose of lithium suppresses acute ketamine-induced oxidative stress. Acute ketamine injection at a dose that produces antidepressant-like effect (50mg/kg) markedly increased lipid peroxidation (a), catalase activity (b), and the levels of oxidized glutathione (c) in the prefrontal cortex (PFC), hippocampus (HPC), and striatum (STR) of stressed mice 20 minutes after injection. Compared with control stressed mice, preketamine treatment with 1200mg/L of lithium for 3 weeks robustly suppressed the oxidative metabolism markers induced by acute ketamine (lithium + ketamine group) in these brain regions. Data are mean±SEM (n =6–10). *P<.05, **P<.01, according to Student–Newman–Keuls multiple comparison test after a one-way analysis of variance (ANOVA).