Figure 5.
Activation of A2A receptors reduces slow afterhyperpolarizations (sAHPs) recorded from basolateral amygdala (BLA) pyramidal neurons. (A) Bar graph quantifying mean amplitude of the sAHP recorded from BLA pyramidal neurons at baseline and following activation of adenosine A2A receptors with 100nM CGS-21680 (*, P=.0384, paired t test; n=11). (B) Sample voltage response to a depolarizing current step recorded from a representative BLA pyramidal cell illustrating the portion of the recoding (grey box) that is magnified in C. (C) Representative voltage traces depicting a reduction in sAHP amplitude following bath application of 100nM CGS-21680. The sAHP was quantified as the mean voltage during a 50-ms window starting 280ms after the cessation of the current step.