Table 3.

Hazard ratios (HRs) and 95 % confidence intervals (CIs) for fractures and potential risk factors in the time-dependent model

Variable	Crude HR (95 % CI)		p-value	Adjusted HR (95 % CI)		p-value
Age, years	1.10	(1.10-1.11)	<0.0001	1.09	(1.08-1.10)	<0.0001
Monthly income, NTD
<= 15000	4.85	(3.98-5.91)	<0.0001	1.34	(1.08-1.66)	0.009
15001-20000	2.25	(1.86-2.71)	<0.0001	1.51	(1.25-1.82)	<0.0001
>20000	1.00	Ref.		1.00	Ref.
Comorbidity (yes vs. no)
Hypertension	4.48	(3.94-5.09)	<0.0001	1.27	(1.09-1.48)	0.002
Hyperlipidemia	2.19	(1.92-2.50)	<0.0001	0.83	(0.72-0.96)	0.01
Diabetes	3.65	(3.18-4.19)	<0.0001	1.59	(1.37-1.85)	<0.0001
PAD	2.74	(2.00-3.74)	<0.0001	0.99	(0.72-1.36)	0.96
Stroke	5.40	(4.27-6.83)	<0.0001	1.38	(1.08-1.76)	0.01
Osteoporosis	3.11	(2.70-3.58)	<0.0001	1.38	(1.19-1.59)	<0.0001
Aromatase inhibitor use before the end point	1.18	(1.00-1.40)	0.049	0.80	(0.68-0.95)	0.01

Manually adjusted for tamoxifen use, age, monthly income, comorbidity and aromatase inhibitor use before the end point

PAD, peripheral artery disease