Table 1.
Frequency of copy number gain (CNG) including PRKACA gene and PRKACA mutations in adrenocortical tumors.
| References | Cortisol-producing ACA | Cortisol-producing ACA with over CS | Cortisol-producing BAH | Cortisol-producing ACC | Non-secreting ACA | Aldosterone-producing ACA | Androgen-producing ACA | Adrenocortical oncocytoma |
|---|---|---|---|---|---|---|---|---|
| Beuschlein et al., 2014 | 22.2% mutations (22/99) | 37% mutations (22/59a) | 1.75% CNG (5/35b) | 0% (0/42) | 0% (0/20) | 0% (0/20) | – | – |
| Cao et al., 2014 | 65.5% p.Leu206Arg (57/87) | NA | 0% (0/13 PMAH) | 0% (0/16) | – | – | – | 0% (0/3) |
| Goh et al., 2014 | 23.6% p.Leu206Arg (57/87) | 35% p.Leu206Arg (10/28) | – | 0% (0/8) | – | – | – | – |
| Di Dalmazi et al., 2014b | 32.3% mutations (22/68c) | 34.3% mutations (22/64c) | 0% (0/8) | 0% (0/5) | – | – | – | – |
| Nakajima et al., 2014 | 14.2% p.Leu206Arg (3/21) | 23% p.Leu206Arg (3/13) | – | – | 0% (0/32) | – | 0% (0/4) | – |
| Sato et al., 2014 | 52.3% p.Leu206Arg (34/65) | 57.1% p.Leu206Arg (32/56) | – | – | – | – | – | – |
| Total | 38.2% (151/395) | 40%(89/220) | 8.9% CNG (5/56) | 0% (0/71) | 0% (0/52) | 0% (0/53) | 0% (0/4) | 0% (0/3) |
a
21/59 harboring p.Leu206Arg and 1/59 with Leu199_Cys200insTrp.
b
31 PPNAD + 2 iMAD+ 2 PMAH.
c
18/22 harboring p.Leu206Arg; 3/22 Cys200_Gly201insVal; 1/22 Ser213Arg+Leu212_Lys214insIle-Ile-Leu-Arg