Table 5.
Meiotic genes and mating pathway genes in P. spp.
| Gene in S. cerevisiae | Ortholog in P. spp. | Function in S. cerevisiae |
|---|---|---|
| csm1 | + | Chromosome segregation |
| csm3 | + | Chromosome segregation |
| dit1 | - | Pyoverdine/dityrosine biosynthesis |
| gsg1 | + | Late post-replication meotic role |
| hop2 | + | Prevents synapsis between non-homologous chromosomes |
| ime1 | - | Meiosis-inducing protein 1 |
| ime2 | + | Kinase, stimulates meiotic gene expression |
| isc10 | - | Sporulation |
| mck1 | + | Kinase required for ime1 expression |
| mek1 | + | A protein kinase that displays genetic interactions with RED1 and HOP1 |
| mnd1 | + | Recombination and meiotic nuclear division |
| msh4 | + | Required for cross-over during meiosis |
| msh5 | + | MutS homolog, facilitates meiotic reciprocal recombination between homologs |
| mum2 | - | Required for premeiotic DNA synthesis and sporulation |
| mum3 | - | Required for premeiotic DNA synthesis and sporulation |
| rad1 | + | DNA repair protein |
| rad17 | + | DNA replication and repair |
| rec12 | - | Meiosis induction |
| red1 | - | Gene required for meiosis I |
| rim4 | - | Activation of sporulation-specific genes |
| smk1 | + | Sporulation specific MAP-kinase |
| spo1 | + | Spindle body duplication |
| spo11 | + | Meiosis initiation by formation of double-strand breaks in DNA |
| spo14 | + | Commitment to meiosis |
| spo22 | - | Chromosome segregation |
| spo75 | + | Required for spore and ascus formation |
| ume6 | - | Regulator of early meiotic gene expression, DNA binding protein |
| zip1 | - | Meiotic chromosome synapse |
| zip2 | - | Meiotic synaptoname complex |
| zip3 | - | Meiotic synaptoname complex |
| zip4 | - | Meiotic synaptoname complex |
| akr1 | + | Required for endocytosis of pheromone receptors |
| cdc24 | + | Required for polarity establishment and maintenance; mutants have morphological defects in bud formation and shmooing |
| cdc42 | + | Essential for establishment and maintenance of cell polarity |
| far1 | + | Inhibitor of Cdc28-Cln complex |
| fus3 | + | Activates Ste12 and Far1 |
| lsg1 | + | Required for mating and sporulation |
| opy2 | + | Overproduction blocks cell cycle arrest in the presence of mating pheromone |
| pea2 | - | Required for phermone-induced pointed projection formation |
| sgv1 | + | Pheromone adaptation |
| spa2 | + | Pheromone-induced morphogenesis and efficient mating. |
| ste2 | + | Pheromone mating factor |
| ste3 | + | Pheromone A receptor |
| ste4 | + | Pheromone signal transduction |
| ste6 | + | ABC-type multidrug transport system |
| ste7 | + | Pheromone signal transduction |
| ste11 | + | Ser/Thr protein kinase; pheromone signal transduction |
| ste12 | + | Activates genes involved in mating or pseudohyphal/invasive growth pathways |
| ste13 | + | Peptidase,mating factor processing |
| ste18 | + | Signal transduction via G-protein-coupled receptors |
| ste20 | + | Activates transcription of FUS1 in the absence of mating pheromone |
| ste50 | + | Essential for activation of conjugation |