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. 2015 May 20;5:10405. doi: 10.1038/srep10405

Figure 6. Effects of hCAR antagonists on PXR activation.

Figure 6

HepG2 cells were transfected with hPXR expression and CYP2B6 luciferase reporter vectors as described in Methods. Twenty-four hours after transfection, cells were treated with vehicle control (0.1% DMSO), CITCO (1 μM), or one of the 10 antagonists at indicated concentrations for another 24 h, in the presence or absence of rifampicin (10 μM). Luciferase activities were determined and expressed relative to vehicle control. Data represents the mean±SD (n = 3).