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. 2015 May 20;5:10405. doi: 10.1038/srep10405

Table 1. Agonist potency (EC50) and efficacy (% in parenthesis) in qHTS.

Compound Name (CAS No.) Chemical Structure Primary Screen Potency [μM] (Efficacy) Follow-up Confirmation Potency [μM] (Efficacy) Known modulator of CAR, CYP2B6, or CYP3A4?
Apomorphine (314-19-2) graphic file with name srep10405-i1.jpg 19 (21%) 13.3 (38%)  
2-Amino-5-chloro-2’-fluorobenzophenone () graphic file with name srep10405-i2.jpg 3.4 (60%) 15.6 (67%)  
Phenelzine (156-51-4) graphic file with name srep10405-i3.jpg 15.1 (145%) 15.9 (70%) CYP3A4 weak inhibitor
Phenoxybenzamine (63-92-3) graphic file with name srep10405-i4.jpg 9.5 (57%) 12 (49%)  
Tracazolate (41094-88-6) graphic file with name srep10405-i5.jpg 17 (27%) 24 (101%)  
Vatalanib (212141-51-0) graphic file with name srep10405-i6.jpg 10.7 (68%) 12.6 (97%)  
Imperatorin (482-44-0) graphic file with name srep10405-i7.jpg 10.7 (146%) 14 (238%) Cyp2b10 inducer
Flavone (525-82-6) graphic file with name srep10405-i8.jpg 34 (184%) 32.4 (200%) Dietary flavonoids activate CAR
Artemotil (75887-54-6) graphic file with name srep10405-i9.jpg 2.1 (33%) 5 (71%) Activates CAR and Induces CYP2B6
Clebopride (55905-53-8) graphic file with name srep10405-i10.jpg 7.6 (52%) 9.4 (80%)