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. Author manuscript; available in PMC: 2016 Jan 7.
Published in final edited form as: Neuron. 2015 Jan 7;85(1):27–47. doi: 10.1016/j.neuron.2014.11.011

Figure 1. Types of gene regulatory sequences and methods for their discovery and characterization.

Figure 1

A) Schematic view of different chromatin states in genic and intergenic regions, with characteristic classes of epigenomic features and an overview of selected methods for their genome-wide mapping. B) Track-style view of features commonly associated with different types of regulatory sequences. C) Transgenic reporter assays enable the validation and detailed characterization of enhancer activity patterns in vitro and in vivo. D) Massive-parallel reporter assays enable medium- and large-scale function-based enhancer discovery screens.