Table 2. Comparison of baseline data (week 0) of Crohn’s disease patients who achieved one-year steroid-free remission at week 52 (responders) with secondary non-responders group.
| Feature | Responders | Non-responders | p |
|---|---|---|---|
| Number of patients (%) | n=44/61 (72%) | n=17/61 (28%) | |
| Age (years) [mean ± SD] | 30 ± 8 | 37 ± 13 | ns |
| Male/female –n (%) | 22/22 | 7/10 | |
| Disease duration (years) [mean ± SD] | 5 ± 3 | 6 ± 5 | ns |
| C-reactive protein (mg/l) [mean ± SD] | 16.4 ± 15.7 | 35.3 ± 38.7 | 0.01 |
| Erythrocyte sedimentation rate (mm/h) [mean ± SD] | 30 ± 18 | 37 ± 23 | ns |
| Red blood cell count (106/mm3) [mean ± SD] | 4.4 ± 0.8 | 4.4 ± 0.7 | ns |
| Hemoglobin (g/dl) [mean ± SD] | 12.5 ± 2.1 | 11.6 ± 2.5 | ns |
| Hematocrit (%) [mean ± SD] | 38 ± 5 | 36 ± 6 | ns |
| White blood cell count (103/mm3) [mean ± SD] | 7.3 ± 3.5 | 7.9 ± 4.2 | ns |
| Platelets (103/mm3) [mean ± SD] | 328 ± 98 | 429 ± 103 | 0.009 |
| Body mass index (kg/m2) [mean ± SD] | 21.2 ± 3 | 20.9 ± 3.3 | ns |
| Crohn’s Disease Activity Index [median (95%CI)] | 264 (220 – 294) | 304 (216 – 331) | ns |
| Simple Endoscopic Score for CD (SES-CD) [median (95%CI)] | 12 (11 – 18) | 12 (4 – 25) | ns |
| Ileal SES-CD [median (95%CI)] | 6 (4 – 7) | 6 (3 – 6) | ns |
| Colonic SES-CD [median (95%CI)] | 9 (6 – 12) | 12 (11 – 18) | ns |
| Disease location – n (%) | |||
| L1 (ileal) | 18/44 (41%) | 9/17 (53%) | ns |
| L3 (ileocolonic) | 26/44 (59%) | 8/17 (47%) | ns |
| Disease behavior – n (%) | |||
| B1 (inflammatory) | 27/44 (61%) | 5/17 (29%) | 0.04 |
| B2 (stricturing) | 6/44 (14%) | 4/17 (24%) | ns |
| B3 (penetrating) | 11/44 (25%) | 8/17 (47%) | ns |
| Previous surgery – n (%) | 15/44 (34%) | 9/17 (53%) | ns |
| Medications | |||
| Steroids | 21/44 (48%) | 5/17 (29%) | ns |
| Azathioprine | 39/44 (87%) | 14/17 (82%) | ns |
| Aminosalicylates | 43/44 (98%) | 17/17 (100%) | ns |
| Probiotics | 33/44 (75%) | 13/17 (76%) | ns |
| Antibiotics | 8/44 (18%) | 7/17 (41%) | ns |
| Previous anti-TNF therapy | 5/44 (11%) | 3/17 (18%) | ns |
Data are presented as means with standard deviations (SD) or medians with 95% confidence intervals (CI).