Table 3.

A Summary of the Studies That Reported an Association Between Diabetes and Medication-Related Osteonecrosis of the Jaw (MRONJ) in Humans.

Study	Study Design	Patients, n	Proportion of DM or IFG With MRONJ (%)	Strength of Correlation Between DM and MRONJ	Comments and Limitations
Khamaisi et al. (2007)	Case control	31	58	P < 0.01	Both DM and IFG were analyzed.
					Data on glucose levels and HbA1c are lacking.
Wilkinson et al. (2007)	Population-based cohort	865 (total DM patients)	19 (DM with complications)	HR = 1.60 (0.48 to 5.31)	Multiple inflammatory/surgical oral complications accounted for the analysis.
Barasch et al. (2011)	Case control	191	17	OR = 1.7 (1.1 to 2.8)	Data on glucose levels and HbA1c are lacking.
Bocanegra-Pérez et al. (2012)	Case control	44	35	NA	Limited data on the DM group
Molcho et al. (2013)	Case control	46	67	P = 0.009	Both DM and IFG were analyzed.
					No correlation with HbA1c
Watters et al. (2013)	Case control	109	22	P = 0.05	Data on glucose levels and HbA1c are lacking.

DM, diabetes mellitus; IFG, impaired fasting glucose; HbA1c, hemoglobin A1c; HR, hazard ratio; OR, odds ratio; NA, not applicable.