Table 4.
Odds ratios for dMCI as defined by eGFR group membership
| dMCI |
||||
|---|---|---|---|---|
| Model 1 |
Model 2 |
Model 3 |
Model 4 |
|
| OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| Age | 1.07∗ (1.01–1.14) | 1.08∗∗ (1.02–1.15) | 1.08∗ (1.02–1.14) | 1.08∗ (1.02–1.15) |
| Sex (male) | 0.98 (0.49–2.01) | 0.95 (0.47–1.94) | 1.01 (0.49–2.02) | 1.01 (0.47–2.20) |
| Education | 0.83∗∗∗ (0.75–0.92) | 0.84∗∗∗ (0.76–0.92) | 0.83∗∗∗ (0.76–0.92) | 0.86∗∗ (0.77–0.95) |
| Caucasian | 0.24∗∗∗ (0.12–0.48) | 0.25∗∗∗ (0.13–0.50) | 0.24∗∗∗ (0.12–0.47) | 0.26∗∗∗ (0.12–0.54) |
| eGFR (low) | 4.30∗∗∗ (1.89–9.81) | 3.21∗∗ (1.40–7.35) | 4.88∗∗∗ (2.04–11.71) | 4.18∗∗ (1.67–10.44) |
| eGFR (moderate) | 1.25 (0.55–2.85) | 1.11 (0.48–2.53) | 1.43 (0.59–3.46) | 1.26 (0.51–3.07) |
| GDS | 0.96 (0.80–1.13) | – | – | 0.99 (0.83–1.18) |
| CVD morbidity | – | 3.05∗ (1.01–9.22) | – | 0.42 (0.14–1.31) |
| APOE ε4 | – | – | 1.75 (0.79–0.87) | 1.86 (0.83–4.16) |
Abbreviations: dMCI, dysexecutive MCI; eGFR, estimated glomerular filtration rate; OR, odds ratio; CI, confidence interval; GDS, Geriatrics Depression Scale; CVD morbidity, cerebrovascular disease morbidity; APOE ε4, apolipoprotein E allele e4.
NOTE. Low eGFR = <60 mL/min/1.73 m2 moderate eGFR = 45–59 mL/min/1.73 m2 high eGFR = ≥60 mL/min/1.73 m2. This includes history of myocardial infarction, history of stroke, diagnosis of diabetes, and hypertension. Model 1 was adjusted for age, sex, education, and race. Model 2 was adjusted for age, sex, education, race, and CVD morbidity. Model 3 was adjusted for age, sex, education, race, and APOE ε4. Model 4 was adjusted for age, sex, education, race, CVD morbidity, and APOE ε4. The high eGFR group was the reference group.
P < .05.
P < .01.
P < .001.