Table III.
Effect of OsteoKing or nilestriol on serum biochemical parameters in OVX rabbits.
| Time-point (days) | Group | Ca2+ (mmol/l) | P (mmol/l) | OC (ng/ml) | PINP (ng/ml) | TRAP5b (mU/ml) | NTX (pmol/ml) |
|---|---|---|---|---|---|---|---|
| 0 | Sham | 3.43±0.07 | 1.59±0.10 | 7.47±1.19 | 2.16±0.52 | 5.98±0.85 | 7.62±0.92 |
| OVX | 3.29±0.12a | 1.26±0.13b | 10.28±1.12b | 3.39±0.71b | 8.68±1.17b | 10.67±1.05b | |
| 60 | Sham | 3.41±0.10 | 1.59±0.13 | 7.53±0.93 | 2.11±0.60 | 6.01±1.29 | 7.50±0.91 |
| Model | 3.34±0.14 | 1.28±0.15b | 10.05±1.45a | 3.36±0.60a | 8.59±0.92b | 10.45±1.51b | |
| Nilestriol | 3.38±0.10 | 1.57±0.12c | 8.41±1.46 | 2.72±0.80 | 6.89±0.95 | 8.18±1.34 | |
| OsteoKing 300 | 3.36±0.16 | 1.48±0.18 | 9.40±1.52 | 3.11±0.49 | 7.81±1.06 | 8.94±1.44 | |
| OsteoKing 600 | 3.37±0.14 | 1.56±0.12c | 8.59±1.38 | 2.69±0.73 | 7.06±1.15 | 8.30±1.26 | |
| 120 | Sham | 3.41±0.10 | 1.58±0.11 | 7.45±0.90 | 2.06±0.56 | 5.81±0.95 | 7.54±0.90 |
| Model | 3.33±0.08 | 1.29±0.09b | 9.79±1.22b | 3.26±0.77a | 8.30±1.27b | 10.26±1.25b | |
| Nilestriol | 3.41±0.10 | 1.58±0.09d | 7.63±0.83c | 1.88±0.46c | 5.67±0.61c | 7.56±0.82d | |
| OsteoKing 300 | 3.39±0.09 | 1.58±0.10d | 8.35±0.93 | 2.22±0.84 | 6.26±0.89c | 8.22±1.05c | |
| OsteoKing 600 | 3.40±0.14 | 1.59±0.08d | 7.75±1.16c | 2.05±0.63c | 5.58±0.77c | 7.55±1.47d |
Values are expressed as the mean ± standard deviation (n=6).
a
P<0.05,
b
P<0.01 vs. sham group;
c
P<0.05,
d
P<0.01 vs. model group. OsteoKing 300/600, ovariectomized and treated with 300/600 mg/kg OsteoKing every other day. OVX, ovariectomized; OC, osteocalcin; PINP, procollagen type I N-terminal peptide; TRAP5b, tartrate-resistant acid phosphatase 5b; NTX, cross-linked N-telopeptide of type I collagen.