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. 2015 Feb 26;12(1):37–44. doi: 10.3892/mmr.2015.3390

Figure 1.

Figure 1

Effects of NAC on mitochondrial function and integrity. Data are presented as the mean ± standard error of the mean of three independent experiments (n=3 per group). ***P<0.001, SCI+VEH mice versus SHAM+VEH mice; ##P<0.01, ###P<0.001, SCI+NAC mice versus SCI+VEH mice; ΔΔP<0.01, ΔΔΔP<0.001, SCI+NAC mice versus SHAM+NAC mice. (A) RCR as a measure of mitochondrial integrity was calculated as the ratio of state III/state IV slopes at 24 h in SHAM and SCI mice treated with NAC or VEH. (B) Mitochondrial respiration rates were calculated as nmols oxygen/min/mg protein at 24 h in SHAM and SCI mice treated with NAC or VEH. NAC, N-acetylcysteine; VEH, vehicle; SCI, spinal cord injury; RCR, respiratory control ratio.