Table 2.
Clinical Characteristics
| Variable | HIV/AIDS N = 56 | Transplant N = 23 | P Value HIV/AIDS vs Transplant | TNF-α Inhibitor N = 11 | P Value HIV/AIDS vs TNF-α Inhibitor |
|---|---|---|---|---|---|
| Severity of illness | |||||
| Mild | 2% | 4% | .5 | 27% | .01 |
| Moderate | 70% | 61% | 45% | ||
| Severe | 29% | 35% | 27% | ||
| Fever (T ≥ 38°C) | 82% | 87% | .8 | 82% | 1.0 |
| Cough | 57% | 39% | .2 | 64% | .8 |
| Diarrhea | 36% | 35% | 1.0 | 18% | .3 |
| Duration of symptoms (days)a | 19 (0–120) | 14 (3–180) | .3 | 14 (4–60) | .8 |
| WBCb (thousand/mL) | 3.2 (0.7–8.9) | 4.3 (1.6–10.8) | .008 | 5.3 (3.8–14.2) | .0004 |
| Hematocrit (%) | 31 (14–47) | 31 (23–39) | .7 | 40 (31–44) | .0003 |
| Platelet count (thousand/mL)c | 127 (14–451) | 191 (51–538) | .04 | 262 (93–489) | .01 |
| Creatinine (mg/dL)c | 0.9 (0.4–12) | 2 (0.9–6.2) | <.0001 | 0.9 (0.7–2.2) | .9 |
| Total bilirubin (mg/dL)c | 0.7 (0.1–5.6) | 1 (0.3–5.6) | .04 | 0.6 (0.4–2.7) | 1.0 |
| AST (U/L)d | 75 (15–1100) | 31 (3–318) | .003 | 72 (20–259) | .2 |
| LDH (U/L)e | 550 (113–15940) | 336 (112–3593) | .07 | 682 (289–871) | .8 |
| Positive blood culturesf | 18/35 (51%) | 4/15 (27%) | .10 | 0/5 (0%) | .04 |
| Positive urine Histo Agg | 43/49 (88%) | 21/22 (95%) | 1.0 | 10/11 (91%) | 1.0 |
| Abnormal CXRh | 32/53 (60%) | 16/23 (70%) | .6 | 9/11 (82%) | .3 |
| Abnormal CTi chest | 27/29 (93%) | 14/16 (87%) | .6 | 8/9 (89%) | 1.0 |
| Adenopathy on CT | 19/29 (66%) | 4/16 (25%) | .01 | 2/9 (22%) | .05 |
| Miliary pattern on CT | 2/29 (7%) | 1/16 (6%) | 1.0 | 4/9 (44%) | .02 |
| Interstitial infiltrates on CT | 8/29 (28%) | 4/16 (25%) | 1.0 | 4/9 (44%) | .4 |
| Alveolar infiltrates on CT | 5/29 (17%) | 6/16 (38%) | .2 | 3/9 (33%) | .4 |
Abbreviations: AIDS, acquired immune deficiency syndrome; AST, aspartate aminotransferase; CT, computed tomography; CXR, chest radiograph; Histo Ag, Histoplasma antigen; HIV, human immunodeficiency virus; LDH, lactate dehydrogenase; TNF, tumor necrosis factor; WBC, white blood cells.
a Duration of symptoms at time of presentation for medical care, median (range).
b WBC at presentation, median (range).
c Median (range).
d AST at presentation, median (range).
e LDH at presentation, median (range).
f Denominator represents number of patients who had fungal blood cultures performed.
g Denominator represents number of patients who had urine antigens performed.
h Denominator represents number of patients who had CXR performed.
i Denominator represents number of patients who had CT performed.