Table III.

Most markedly dysregulated genes, sorted by FDR, in ESCC tissue compared with normal tissue.

A, Upregulated in ESCC
mRNA	P-value	FDR	Fold change
COL1A1	7.07×10−154	1.27×10−149	13.06
COL10A1	1.35×10−147	1.61×10−143	38.33
MMP1	8.01×10−134	4.41×10−130	30.41
POSTN	3.21×10−132	1.35×10−128	16.70
SPP1	6.29×10−127	2.05×10−123	31.89
AURKA	1.52×10−125	4.18×10−122	5.36
FSCN1	1.84×10−122	4.26×10−119	5.17
ADAMTS12	5.51×10−122	1.19×10−118	17.63
LAMC2	2.96×10−121	6.06×10−118	11.52
MFAP2	1.66×10−120	3.12×10−117	12.31

B, Downregulated in ESCC
mRNA	P−value	FDR	Fold change
EMP1	6.05×10−148	8.66×10−144	0.08
GCOM1	4.37×10−147	4.47×10−143	0.05
PPP1R3C	2.21×10−144	1.58×10−140	0.06
ELN	3.60×10−142	2.35×10−138	0.13
MAL	2.08×10−132	9.30×10−129	0.04
MGLL	1.77×10−128	6.66×10−125	0.18
CRISP2	3.21×10−127	1.15×10−123	0.01
SH3BGRL2	6.31×10−127	2.05×10−123	0.07
SASH1	1.55×10−126	4.62×10−123	0.11
CAB39L	1.07×10−125	3.07×10−122	0.16

ESCC, esophageal squamous cell carcinoma; FDR, false discovery rate; miR, microRNA.