Figure 4.

SST reduces the expression of LPS-induced pro-inflammatory mediators. At 24 h after LPS injection, the amounts of (A) TNF-α, (B) IL-1β and (C) PGE2 in the SN were measured using ELISA. Values are presented as the mean ± standard error of the mean of eight animals per group; ^*P<0.05, **P<0.01 and ^***P<0.001 compared with the phosphate-buffered saline-injected SN. LPS, lipopolysaccharide; SST, somatostatin; SN, substantia nigra; TNF, tumor necrosis factor; IL, interleukin; PGE, prostaglandin E2.