Figure 5.

Effect of SST on LPS-induced expression of Cox-2, iNOS and the activation of NF-κB p65. l. (A and C) representative western blot gels showing Cox-2, iNOS, NF-κB p65 and NF-κB p-p65 levels. Cox-2, iNOS and NF-κB p-p65 are represented by the bands at 21, 130 and 65 kDa, respectively. β-actin was used as an internal control. (B and D) Quantification of A and C by gray value analysis. Values are presented as the mean ± standard error of the mean of eight animals per group. ^*P<0.05, ^**P<0.01, ^***P<0.001 compared with phosphate-buffered saline-injected SN. LPS, lipopolysaccharide; SST, somatostatin; SN, substantia nigra; COX, cyclooxygenase; iNOS, inducible nitric oxide synthase; NF-κB, nuclear factor kappa B.