Table II.

Overrepresentation analysis of proteins predominantly expressed in the testis and epididymis.

A, Predominantly expressed testicular proteins
GO term	Candidates contained, n (%)	P-value
GO:0007276 gamete generation	84 (15.8)	1.89×10−12
GO:0007126 meiosis	29 (17.7)	4.04×10−06
GO:0048515 spermatid differentiation	19 (22.4)	5.83×10−06
GO:0051321 meiotic cell cycle	29 (17.3)	6.60×10−06
GO:0009566 fertilization	21 (19.3)	2.22×10−05
GO:0007281 germ cell development	24 (17.1)	4.50×10−05
GO:0030317 sperm motility	9 (27.3)	3.53×10−04
GO:0003188 heart valve formation	5 (45.5)	5.67×10−04
GO:0007049 cell cycle	130 (9.2)	1.14×10−03
GO:0007548 gender differentiation	31 (12.3)	1.98×10−03
GO:0007128 meiotic prophase I	6 (28.6)	2.67×10−03
GO:0051301 cell division	51 (10.5)	3.33×10−03
GO:0007530 gender determination	6 (25.0)	5.53×10−03
GO:0048608 reproductive structure development	30 (11.3)	7.33×10−03
GO:0035036 sperm-egg recognition	5 (26.3)	8.87×10−03
B, Predominantly expressed epididymal proteins
GO term	Candidates contained, n (%)	P-value
GO:0007155 cell adhesion	91 (9.4)	3.37×10−03
GO:0042221 response to chemical stimulus	241 (8.2)	5.74×10−03
GO:0030855 epithelial cell differentiation	34 (11.1)	5.88×10−03
GO:0006612 protein targeting to membrane	20 (12.8)	6.95×10−03
GO:0051641 cellular localization	178 (8.4)	7.49×10−03
GO:0008104 protein localization	142 (8.6)	7.50×10−03
C, Epididymal fluid proteins
GO term	Candidates contained, n (%)	P-value
GO:0006629 lipid metabolic process	34 (2.9)	1.64×10−05
GO:0009056 catabolic process	47 (2.3)	1.09×10−04
GO:2000145 regulation of cell motility	16 (3.7)	1.89×10−04
GO:0008233 peptidase activity	19 (3.2)	3.37×10−04
GO:0004857 enzyme inhibitor activity	13 (4.0)	4.03×10−04
GO:0006979 response to oxidative stress	10 (3.9)	2.10×10−03
GO:0006508 proteolysis	24 (2.4)	3.02×10−03
GO:0009566 fertilization	6 (5.5)	3.21×10−03
GO:0051604 protein maturation	7 (4.2)	6.51×10−03
GO:0050776 regulation of immune response	16 (2.5)	9.20×10−03

GO, gene ontology.