Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Mar 20;12(1):877–884. doi: 10.3892/mmr.2015.3524

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

PMC Copyright notice

GTX protects BMP-2-induced osteoblast differentiation against inhibition by TNF-α; evidence from ALP staining and gene expression levels of transcription factors. (A) ALP staining assay revealed that 1 μg/ml GTX protected ALP activity against TNF-α-induced inhibition. (B–D) GTX (1 μg/ml) rescued the gene expression of Runx2, Osx and ATF4 following TNF-α-induced inhibition. ^*P<0.05, ^**P<0.01, n>3. GTX, gliotoxin; TNF-α, tumor necrosis factor-α; ALP, alkaline phosphatase; mRNA, messenger RNA; BMP-2, bone morphogenetic protein-2.