Figure 4.
MRI signal intensity and durability at different time-points in labeled cells. (A) A total of 1×106 cells were detected by clinical MRI. The T1WI signal and relevant SNR of BMSCs were observed to be attenuated with progressing cell division and proliferation. (B and C) The MRI-derived quantitative T1WI signal intensity and SNR data of labeled BMSCs increased significantly from 1–28 days compared with that in non-labeled BMSCs (BMSCs + Agar) (*P<0.05). The MRI signal intensity in the labeled groups at 1, 3 and 7 days subsequent was higher than that in BMSCs with Gd but non-FI (BMSCs + Gd/non-FI) (#P<0.05). MRI, magnetic resonance imaging; T1WI, T1 weighted image; SNR, signal-to-noise ratio; BMSCs, bone marrow stromal cells; Gd/FI, gadodiamide/FI-Arrest In reagent; PLL, poly lysine.