Table I.
Sequence variations in epidermal growth factor receptor gene among the 59 mutated cases found.
| No. of positive cases (%) | EGFR exon | DNA change | Amino acid change | Effect | Designation |
|---|---|---|---|---|---|
| 1 (1.7) | 18 | c.2154 G>C | p.Gly719Ala | Missense | G719A |
| 22 (37.2) | 19 | c.2235-2249 del15 | p.del746_750 | In-frame deletion | delELREA |
| 1 (1.7) | 19 | c.2237_2255 del18>TT | p.del746_S752>V | In-frame deletion complex | delELREATS>V |
| 1 (1.7) | 19 | c.2235_2249 del15 | p.del745_750 | In-frame deletion | delKELREA |
| 1 (1.7) | 19 | c.2239_2251 del13; 2253_2254insA | p.del747_750 | In-frame deletion complex | delLREA |
| 1 (1.7) | 19 | c.2239_2248 del10; 2248_2249ins | p.del747_749 | In-frame deletion complex | delLRE |
| 1 (1.7) | 19 | c.2239_2253 del15 | p.del747_751 | In-frame deletion | delLREAT |
| 2 (3.4) | 19 | c.2252C>G; 2253_2277 del24 | p.T751S; del752_759 | In-frame deletion complex | delSPKANKEI |
| 1 (1.7) | 19 | c.2239_2240 TT>CC | p.Leu747Pro | Missense | L747P |
| 1 (1.7) | 21 | c.2572 C>A | p.Leu858Met | Missense | L858M |
| 1 (1.7) | 21 | c.2582 T>A | p.Leu861Gln | Missense | L861Q |
| 26 (44.1) | 21 | c.2573 T>G | p.Leu858Arg | Missense | L858R |