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. 2015 Feb 16;12(1):226–232. doi: 10.3892/mmr.2015.3357

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Copyright © 2015, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Repression of MTDH expression enhances prostate cancer cell sensitivity to cisplatin. (A and B) Compared with control group C, MTDH messenger RNA and protein expression were significantly lower in the intervention group D (^*P<0.01). (C and D) An apoptosis assay, (E) an MTT assay for cell viability and (F and G) a Transwell chamber invasion assay with hematoxylin staining (magnification, x400) were also performed. The results suggested that intervention group D had a higher apoptotic rate, lower cell viability and weaker cell invasive ability than the control group C (^*P<0.05). MTDH, metadherin; FITC, fluorescein isothiocyanate.