Table II.
Downregulation of gene expressions in catharidine-treated NCI-H460 cells.
| Probe set ID | Fold change | Gene symbol | Gene description | mRNA accession no. |
|---|---|---|---|---|
| 8175016 | −3.08 | APLN | Apelin | NM_017413 |
| 8124413 | −3.06 | HIST1H4D | Histone cluster 1, H4d | NM_003539 |
| 8105302 | −3.05 | FST | Follistatin | NM_006350 |
| 7953665 | −3.04 | DPPA3 | Developmental pluripotency-associated 3 | NM_199286 |
| 8117426 | −2.99 | HIST1H2BH | Histone cluster 1, H2bh | NM_003524 |
| 8117898 | −2.97 | HIST1H4J | Histone cluster 1, H4j | NM_021968 |
| 8117337 | −2.95 | HIST1H1E | Histone cluster 1, H1e | NM_005321 |
| 7911241 | −2.93 | OR2L8 | Olfactory receptor, family 2, subfamily L, member 8 | NM_001001963 |
| 8048749 | −2.88 | KCNE4 | Potassium voltage-gated channel, IsK-related family, member 4 | NM_080671 |
| 8124437 | −2.87 | HIST1H3F | Histone cluster 1, H3f | NM_021018 |
| 8117395 | −2.83 | HIST1H2BF | Histone cluster 1, H2bf | NM_003522 |
| 8015798 | −2.79 | LOC100130581 | Hypothetical LOC100130581 | NR_027413 |
| 7919642 | −2.78 | HIST2H2AB | Histone cluster 2, H2ab | NM_175065 |
| 8059470 | −2.76 | IRS1 | Insulin receptor substrate 1 | NM_005544 |
| 8077270 | −2.75 | CHL1 | Cell adhesion molecule with homology to L1 cell adhesion molecule | NM_006614 |
| 7915592 | −2.74 | RNU5D | RNA, U5D small nuclear | NR_002755 |
| 7906767 | −2.74 | FCGR2C | Fc fragment of immunoglobulin G, low affinity IIc, receptor for (CD32) (gene/pseudogene) | NM_201563 |
| 8117594 | −2.74 | HIST1H2BM | Histone cluster 1, H2bm | NM_003521 |
| 8117589 | −2.72 | HIST1H3H | Histone cluster 1, H3h | NM_003536 |
| 7981728 | −2.71 | LOC100293211 | Similar to hCG2042717 | ENST00000390601 |
| 8124397 | −2.71 | HIST1H1C | Histone cluster 1, H1c | NM_005319 |
| 8135734 | −2.71 | C7orf58 | Chromosome 7 open reading frame 58 | NM_024913 |
| 8138988 | −2.70 | DPY19L2P1 | Dpy-19-like 2 pseudogene 1 (C. elegans) | NR_002833 |
| 8117583 | −2.65 | HIST1H2AI | Histone cluster 1, H2ai | NM_003509 |
| 8153258 | −2.65 | SLC45A4 | Solute carrier family 45, member 4 | BC033223 |
| 7960865 | −2.61 | SLC2A3 | Solute carrier family 2 (facilitated glucose transporter), member 3 | NM_006931 |
| 8116921 | −2.59 | EDN1 | Endothelin 1 | NM_001955 |
| 8101757 | −2.58 | GPRIN3 | G protein-regulated inducer of neurite outgrowth family member 3 | NM_198281 |
| 7971723 | −2.58 | FLJ37307 | Hypothetical LOC283521 | NR_027047 |
| 8117580 | −2.56 | HIST1H2AI | Histone cluster 1, H2ai | NM_003509 |
| 8167573 | −2.56 | GAGE1 | G antigen 1 | NM_001468 |
| 8165295 | −2.56 | LCN8 | Lipocalin 8 | ENST00000371686 |
| 7927876 | −2.53 | TET1 | Ten-eleven translocation oncogene 1 | NM_030625 |
| 7963054 | −2.52 | TUBA1A | Tubulin, α1a | NM_006009 |
| 7957386 | −2.51 | ACSS3 | Acyl-CoA synthetase short-chain family member 3 | NM_024560 |
| 7915919 | −2.49 | TAL1 | T cell acute lymphocytic leukemia 1 | NM_003189 |
| 8174985 | −2.48 | SMARCA1 | Switch/sucrose non-fermentable-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 1 | NM_003069 |
| 8105495 | −2.47 | PART1 | Prostate androgen-regulated transcript 1 (non-protein coding) | NR_028508 |
| 8146967 | −2.46 | CRISPLD1 | Cysteine-rich secretory protein LCCL domain-containing 1 | NM_031461 |
| 8144786 | −2.46 | SLC7A2 | Solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | NM_003046 |
| 8029280 | −2.45 | CD177 | CD177 molecule | NM_020406 |
| 7984524 | −2.45 | PAQR5 | Progestin and adipoQ receptor family member V | NM_001104554 |
| 7973182 | −2.44 | LOC554207 | Hypothetical LOC554207 | ENST00000320322 |
| 8145795 | −2.44 | LOC100293539 | Similar to ribosomal protein 10 | XM_002346094 |
| 8095697 | −2.44 | CXCL1 | Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, α) | NM_001511 |
| 8124406 | −2.42 | HIST1H2BC | Histone cluster 1, H2bc | NM_003526 |
| 7978260 | −2.42 | DHRS1 | Dehydrogenase/reductase family member 1 | NM_001136050 |
| 7920271 | −2.42 | S100A4 | S100 calcium binding protein A4 | NM_019544 |
| 8166469 | −2.42 | SAT1 | Spermidine/spermine N1-acetyltransferase 1 | NR_027783 |
| 8124527 | −2.40 | HIST1H1B | Histone cluster 1, H1b | NM_005322 |
| 8008321 | −2.40 | ACSF2 | Acyl-CoA synthetase family member 2 | NM_025149 |
| 8124385 | −2.39 | HIST1H4B | Histone cluster 1, H4b | NM_003544 |
| 800731 | −2.38 | TUBG2 | Tubulin, γ2 | NM_016437 |
| 8122365 | −2.36 | GPR126 | G protein-coupled receptor 126 | NM_020455 |
| 8015273 | −2.34 | KRT31 | Keratin 31 | NM_002277 |
| 7904465 | −2.34 | HIST2H2BA | Histone cluster 2, H2ba | NR_027337 |
| 8124416 | −2.33 | HIST1H3D | Histone cluster 1, H3d | NM_003530 |
| 8074458 | −2.33 | C22orf39 | Chromosome 22 open reading frame 39 | NM_173793 |
| 8046048 | −2.33 | CSRNP3 | Cysteine-serine-rich nuclear protein 3 | NM_001172173 |
| 8007493 | −2.32 | ARL4D | Adenosine diphosphate-ribosylation factor-like 4D | NM_001661 |
| 8157804 | −2.31 | OLFML2A | Olfactomedin-like 2A | NM_182487 |
| 7948836 | −2.31 | TMEM223 | Transmembrane protein 223 | NM_001080501 |
| 8033458 | −2.31 | LYPLA2 | Lysophospholipase II | NM_007260 |
| 7919619 | −2.30 | HIST2H2AA3 | histone cluster 2, H2aa3 | NM_003516 |
| 7905079 | −2.30 | HIST2H2AA3 | Histone cluster 2, H2aa3 | NM_003516 |
| 7927631 | −2.29 | DKK1 | Dickkopf homolog 1 (Xenopus laevis) | NM_012242 |
| 7975598 | −2.28 | ACOT1 | Acyl-CoA thioesterase 1 | NM_001037161 |
| 8071801 | −2.27 | GSTTP1 | Glutathione S-transferase θ pseudogene 1 | NR_003081 |
| 7928429 | −2.27 | PLAU | Plasminogen activator, urokinase | NM_002658 |
| 8068898 | −2.27 | HIST1H2BK | Histone cluster 1, H2bk | NM_080593 |
| 8041467 | −2.26 | VIT | Vitrin | NM_053276 |
| 8077160 | −2.26 | ARSA | Arylsulfatase A | NM_000487 |
| 7991754 | −2.25 | HBZ | Hemoglobin, ζ | NM_005332 |
| 8049534 | −2.24 | LRRFIP1 | Leucine-rich repeat (in FLII) interacting protein 1 | NM_001137550 |
| 7909789 | −2.23 | TGFB2 | Transforming growth factor β2 | NM_001135599 |
| 7919612 | −2.23 | HIST2H3D | Histone cluster 2, H3d | NM_001123375 |
| 8100578 | −2.22 | EPHA5 | Ephrin receptor A5 | NM_004439 |
| 8169541 | −2.22 | DOCK11 | Dedicator of cytokinesis 11 | NM_144658 |
| 8124430 | −2.21 | HIST1H1D | Histone cluster 1, H1d | NM_005320 |
| 8124524 | −2.21 | HIST1H2AK | Histone cluster 1, H2ak | NM_003510 |
| 8124524 | −2.21 | HIST1H2AK | Histone cluster 1, H2ak | NM_003510 |
| 7906775 | −2.20 | HSPA7 | Heat shock 70kDa protein 7 (HSP70B) | NR_024151 |
| 7953291 | −2.20 | CD9 | CD9 molecule | NM_001769 |
| 8033319 | −2.19 | SH2D3A | Src Homology 2 domain-containing 3A | NM_005490 |
| 7905088 | −2.19 | HIST2H2AC | Histone cluster 2, H2ac | NM_003517 |
| 7975602 | −2.19 | ACOT2 | Acyl-CoA thioesterase 2 | NM_006821 |
| 7982854 | −2.19 | DLL4 | δ-like 4 (Drosophila) | NM_019074 |
| 8019778 | −2.19 | PCYT2 | Phosphate cytidylyltransferase 2, ethanolamine | NM_002861 |
| 8046048 | −2.19 | HIST1H4C | Histone cluster 1, H4c | NM_003542 |
| 8007493 | −2.18 | VWA5A | Von Willebrand factor A domain-containing 5A | NM_001130142 |
| 8157804 | −2.18 | PLG | Plasminogen | NM_000301 |
| 7948836 | −2.18 | CD24 | CD24 molecule | NM_013230 |
| 8033458 | −2.17 | FSTL4 | Follistatin-like 4 | NM_015082 |
| 7919619 | −2.16 | CA2 | Carbonic anhydrase II | NM_000067 |
| 7905079 | −2.16 | CDH19 | Cadherin 19, type 2 | NM_021153 |
| 7927631 | −2.16 | CDC42EP3 | Cell division cycle 42 effector protein (Rho guanosine triphosphatase binding) 3 | NM_006449 |
| 7975598 | −2.16 | ACCN2 | Amiloride-sensitive cation channel 2, neuronal | NM_020039 |
| 8071801 | −2.15 | HIST2H3D | Histone cluster 2, H3d | NM_001123375 |
| 7928429 | −2.15 | RFX2 | Regulatory factor X, 2 (influences human leukocyte antigen class II expression) | NM_000635 |
| 8068898 | −2.15 | NES | Nestin | NM_006617 |
| 8041467 | −2.15 | LOC25845 | Hypothetical LOC25845 | NR_024158 |
| 8077160 | −2.15 | THSD7A | Thrombospondin, type I, domain-containing 7A | NM_015204 |
| 7991754 | −2.14 | LOC147727 | Hypothetical LOC147727 | NR_024333 |
| 8049534 | −2.14 | CALML6 | Calmodulin-like 6 | NM_138705 |
| 7909789 | −2.14 | DEFB109P1B | Defensin, β 109, pseudogene 1B | NR_003668 |
| 7919612 | −2.13 | EPOR | Erythropoietin receptor | NM_000121 |
| 8100578 | −2.13 | EEF2K | Eukaryotic elongation factor-2 kinase | NM_013302 |
| 8169541 | −2.13 | EMP3 | Epithelial membrane protein 3 | NM_001425 |
| 8124430 | −2.13 | TMEM84 | Transmembrane protein 84 | NR_026949 |
| 8124524 | −2.13 | CXXC5 | CXXC finger 5 | NM_016463 |
| 7906775 | −2.12 | PCYT2 | Phosphate cytidylyltransferase 2, ethanolamine | NM_002861 |
| 7953291 | −2.12 | LYPD1 | Ly6/plasminogen activator, urokinase 1 receptor domain-containing | NM_144586 |
| 8033319 | −2.12 | PHLDB2 | Pleckstrin homology-like domain, family B, member 2 | NM_001134439 |
| 7905088 | −2.11 | LRFN2 | Leucine-rich repeat and fibronectin type III domain-containing 2 | NM_020737 |
| 7975602 | −2.11 | C9orf23 | Chromosome 9 open reading frame 23 | NM_148179 |
| 7982854 | −2.11 | FLJ13744 | Hypothetical FLJ13744 | BC070061 |
| 8018445 | −2.11 | UNK | Unkempt homolog (Drosophila) | NM_001080419 |
| 8038407 | −2.10 | RRAS | Related RAS viral (r-ras) oncogene homolog | NM_006270 |
| 7987230 | −2.10 | LPCAT4 | Lysophosphatidylcholine acyltransferase 4 | NM_153613 |
| 8031514 | −2.10 | LOC100133142 | Hypothetical LOC100133142 | XM_001718400 |
| 8130374 | −2.10 | FBXO5 | F-box protein 5 | NM_012177 |
| 7908409 | −2.09 | RGS2 | Regulator of G-protein signaling 2 | NM_002923 |
| 8111255 | −2.09 | CDH10 | Cadherin 10, type 2 (T2-cadherin) | NM_006727 |
| 7965335 | −2.09 | DUSP6 | Dual specificity phosphatase 6 | NM_001946 |
| 8065537 | −2.09 | LOC100134868 | Hypothetical LOC100134868 | NR_004846 |
| 8138466 | −2.08 | MACC1 | Metastasis associated in colon cancer 1 | NM_182762 |
| 7902687 | −2.08 | CYR61 | Cysteine-rich, angiogenic inducer, 61 | NM_001554 |
| 8036136 | −2.08 | TMEM149 | Transmembrane protein 149 | NM_024660 |
| 8098916 | −2.08 | TMEM129 | Transmembrane protein 129 | NM_001127266 |
| 7955663 | −2.07 | TENC1 | Tensin-like C1 domain-containing phosphatase (tensin 2) | NM_170754 |
| 7939897 | −2.07 | FOLH1 | Folate hydrolase (prostate-specific membrane antigen) 1 | NM_004476 |
| 7920191 | −2.07 | LCE3A | Late cornified envelope 3A | NM_178431 |
| 7951437 | −2.06 | GUCY1A2 | Guanylate cyclase 1, soluble, α2 | NM_000855 |
| 8022653 | −2.06 | LOC728606 | Hypothetical LOC728606 | NR_024259 |
| 7929816 | −2.06 | SCD | Stearoyl-CoA desaturase (δ-9-desaturase) | NM_005063 |
| 7940565 | −2.06 | FADS2 | Fatty acid desaturase 2 | NM_004265 |
| 7951157 | −2.06 | CCDC82 | Coiled-coil domain-containing 82 | AK313893 |
| 7936100 | −2.06 | CALHM2 | Calcium homeostasis modulator 2 | NM_015916 |
| 7954090 | −2.06 | EMP1 | Epithelial membrane protein 1 | NM_001423 |
| 8005951 | −2.05 | SNORD42B | Small nucleolar RNA, C/D box 42B | NR_000013 |
| 8148917 | −2.05 | MFSD3 | Major facilitator superfamily domain-containing 3 | NM_138431 |
| 7937990 | −2.04 | HBG1 | Hemoglobin, γA | NM_000559 |
| 7937993 | −2.04 | HBG2 | Hemoglobin, γG | NM_000184 |
| 8033233 | −2.04 | TUBB4 | Tubulin, β4 | NM_006087 |
| 8048350 | −2.04 | PLCD4 | Phospholipase C, δ4 | NM_032726 |
| 8037408 | −2.04 | KCNN4 | Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 | NM_002250 |
| 7964119 | −2.04 | STAT2 | Signal transducer and activator of transcription 2 | NM_005419 |
| 8016841 | −2.03 | TMEM100 | Transmembrane protein 100 | NM_001099640 |
| 7958948 | −2.03 | DDX54 | DEAD box polypeptide 54 | NM_0011111322 |
| 8151512 | −2.02 | PAG1 | Phosphoprotein associated with glycosphingolipid microdomains 1 | NM_018440 |
| 8005549 | −2.02 | GRAPL | Growth factor receptor-bound protein 2-related adaptor protein-like | NM_001129778 |
| 8033159 | −2.02 | PSPN | Persephin | NM_004158 |
| 7986639 | −2.02 | VSIG6 | V-set and immunoglobulin domain-containing 6 | ENST00000338567 |
| 7938741 | −2.01 | MRGPRX3 | MAS-related G protein coupled receptor, member X3 | NM_054031 |
| 8047174 | −2.01 | SLC39A10 | Solute carrier family 39 (zinc transporter), member 10 | NM_001127257 |
Acyl-CoA, acyl coenzyme A; DEAD, (Asp-Glu-Ala-Asp).