Table 2.
Entrya | Name | M/I ratio | Eff (%)b | Loading (%)c | Size (nm)d | PDIe |
---|---|---|---|---|---|---|
1 | CPT-N-PLA100 NC | 100 | >95 | 2.3 | 82 | 0.06 |
2 | CPT-N-PLA50 NC | 50 | >95 | 4.6 | 89 | 0.09 |
3 | CPT-N-PLA10 NC | 10 | >95 | 18.5 | 73 | 0.12 |
Abbreviation: NC = Nanoconjugates; M/I = monomer/initiator ratio; Eff = incorporation efficiency, the percent of initiator utilized in the initiation of LA polymerization; PDI = polydispersity derived from particle sizing using DLS. NCs are named as CPT-N-PLAM/I.
the data was based on the reversed-phase HPLC analysis of unincorporated drug.
the data was based on the reversed-phase HPLC analysis of unincorporated drug.
characterized by DLS.
characterized by DLS.