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. Author manuscript; available in PMC: 2016 Jun 10.
Published in final edited form as: J Control Release. 2015 Apr 7;207:70–76. doi: 10.1016/j.jconrel.2015.04.001

Fig. 4.

Fig. 4

Humoral immune responses induced by PR8-amiR-93NP and protection against wild PR8 influenza virus in mice. Mice (n=8) were vaccinated with different doses of PR8-amiR-93NP and bled at days 0, 15 and 29 post-vaccination. At 29 days post-vaccination, Mice (n=8) were challenged with 100×LD50.HA-specific antibodies IgG (A), IgG1 (B), and IgG2a (C) were measured by ELISA. (* p>0.05, **p<0.05). (D) Mouse weight change after challenge and (E) survival rate (* p>0.05) are shown.