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. 2015 May 20;10(5):e0127404. doi: 10.1371/journal.pone.0127404

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© 2015 Yu et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 2 — The size of the nodes corresponds to the number of treatment study trials. Direct comparison treatments are linked with a line noting the number of trials. The thickness of the line corresponds to the number of trials that studied this comparison. Node: T-DM1; LC, lapatinib; HC, trastuzumab; NST, naïve standard treatments; PEHC, pertuzumab and trastuzumab; PEC, pertuzumab; LHC, lapatinib and trastuzumab.