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. 2015 May 20;10(5):e0127071. doi: 10.1371/journal.pone.0127071

Table 4. Therapy at baseline and month-12 visit.

Overall (n = 729) HTN (n = 392) DN (n = 116) GN (n = 126) TIN (n = 69) PKD (n = 26) P
LSD (%)
 Baseline 22.8 25.6 18.0 19.3 23.1 16.7 0.354
 Month 12 26.2 26.4 31.5* 19.3 29.2 25.0 0.301
BP lowering drugs (n)
 Baseline 2.2±1.3 2.5±1.2 2.5±1.2 1.7 ±1.3 1.0±1.1 1.6±1.6 <0.0001
 Month 12 2.7±1.4* 2.8±1.2* 3.3±1.5* 2.5±1.4* 1.5±1.4* 2.0±1.4* <0.0001
RAS inhibitors (%)
 Baseline 74.9 82.1 77.4 67.5 54.3 69.2 <0.0001
 Month 12 85.3* 88.8* 75.6 88.9* 60.0* 76.9 <0.0001
B-blockers (%)
 Baseline 27.4 33.9 30.4 16.7 5.8 24.0 <0.0001
 Month 12 36.7* 41.1* 46.1* 27.8* 14.5* 32.0 <0.0001
CCBs (%)
 Baseline 34.9 39.0 48.7 20.6 17.4 28.0 <0.0001
 Month 12 43.9* 48.7* 60.9* 26.2 24.6 32.0 <0.0001
Furosemide (%)
 Baseline 23.1 25.0 33.9 19.0 8.7 4.0 <0.0001
 Month 12 34.3* 34.4* 51.3* 34.9* 11.6 12.0 <0.0001
ESA (%)
 Baseline 3.0 2.6 0.9 5.6 4.3 3.8 0.256
 Month 12 14.4* 14.3* 19.1* 12.7* 12.9* 7.7 0.482
Iron supplement (%)
 Baseline 4.1 4.3 3.5 1.6 8.7 4.0 0.210
 Month 12 18.2* 16.3* 26.1* 17.5* 14.5 24.0 0.136
Statins (%)
 Baseline 30.0 31.1 45.2 26.2 10.1 16.9 <0.0001
 Month 12 43.7* 45.7* 55.7* 38.1* 29.0* 28.0 0.002
Vitamin D (%)
 Baseline 4.0 3.1 0.9 7.1 8.7 4.0 0.026
 Month 12 13.9* 12.5* 9.6* 21.4* 14.5 16.0 0.074
P binders (%)
 Baseline 0.3 0.3 0 0.8 0 0 0.769
 Month 12 2.1* 1.3 4.3 0.8 4.3 4.0 0.115

Data are mean±SD or % of patients and (95%CI). RAS, renin-angiotensin system; BP, blood pressure; LSD, low salt diet (UNaV <100 mmol/24h); ESA, erythropoiesis stimulating agents.

* P<0.05 versus baseline