Table 5. Multivariable Cox models of determinants of the combined renal endpoint.
| Unadjusted | Model 1 | Model 2 | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | HR | 95% CI | R2R (%) | |
| Cause of kidney disease | 15.0 | ||||||
| HTN | Ref. | Ref. | Ref. | ||||
| DN | 2.72 | 1.84–4.03 | 2.44 | 1.63–3.66 | 1.96 | 1.28–2.99 | |
| GN | 1.54 | 1.00–2.36 | 2.38 | 1.46–3.87 | 1.39 | 0.83–2.31 | |
| TIN | 1.33 | 0.75–2.34 | 1.61 | 0.86–3.01 | 1.80 | 0.95–3.41 | |
| PKD | 3.64 | 2.03–6.53 | 5.01 | 2.57–9.74 | 5.46 | 2.28–10.6 | |
| Blood pressure goal | 8.0 | ||||||
| Unachieved at month 12 (n = 361) | Ref. | Ref. | Ref. | ||||
| Achieved only at month 12 (n = 184) | 0.57 | 0.39–0.84 | 0.52 | 0.35–0.78 | 0.59 | 0.39–0.89 | |
| Achieved at both visits (n = 182) | 0.35 | 0.22–0.56 | 0.42 | 0.26–0.68 | 0.46 | 0.28–0.76 | |
| Hemoglobin goal | 7.0 | ||||||
| Unachieved at month 12 (n = 74) | Ref. | Ref. | Ref. | ||||
| Achieved only at month 12 (n = 74) | 0.55 | 0.32–0.95 | 0.45 | 0.26–0.79 | 0.48 | 0.27–0.85 | |
| Achieved at both visits (n = 579) | 0.34 | 0.23–0.50 | 0.42 | 0.28–0.64 | 0.44 | 0.29–0.68 | |
| Proteinuria goal | 13.0 | ||||||
| Unachieved at month 12 (n = 202) | Ref. | Ref. | Ref. | ||||
| Achieved only at month 12 (n = 73) | 0.35 | 0.19–0.65 | 0.38 | 0.20–0.72 | 0.44 | 0.23–0.83 | |
| Achieved at both visits (n = 452) | 0.33 | 0.24–0.46 | 0.38 | 0.27–0.54 | 0.43 | 0.29–0.62 | |
Model 1: diagnoses and goals are separately adjusted for main covariates (age, gender, history of CV disease, BMI, eGFR, use of RAS inhibitors). Model 2: fully adjusted (adjusted for main covariates of model 1 plus diagnoses and therapeutic goals). See Methods for definition of goal values. HTN, hypertensive nephropathy; DN, diabetic nephropathy; GN, glomerulonephritis; PKD, autosomal polycystic kidney disease; TIN, tubulointerstitial nephropathy. R2R, R2 reduction.