Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 May 20;10(5):e0127081. doi: 10.1371/journal.pone.0127081

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 Forse et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Fig 3 — (A) The ephrin-A5-bound EphA3 LBD (colored wheat) superimposes well to the EphA LBDs from other EphA/ephrin-A structures (depicted as grey lines; 0.5–0.7 Å RMSD to PDBIDs 3MX0 (EphA2/ephrin-A5), 3HEI (EphA2/ephrin-A1), and 2WO3 (EphA4/ephrin-A2)). (B) Ephrin-A5 (colored light blue) superimposes well to previously available ephrin-A5 structures (0.5–0.6 Å RMSD to PDBIDs 1SHX (unbound ephrin-A5), 1SHW (EphB2/ephrin-A5), 3MX0 (EphA2/ephrin-A5), and 2X11 (EphA2/ephrin-A5)). (C) The EphA3/ephrin-A5 complex superimposes less well to other EphA/ephrin-A complexes (1.7–2.1 Å RMSD compared to 3MX0, 2X11, 2WO3 and 3HEI). (D) Superposition of the EphA2/ephrin-A5 complex (PDBID 3MX0) to just the EphA3 LBD reveals that ephrin-A5 is tilted by 9° in the EphA3/ephrin-A5 structure compared to its orientation in complex with EphA2. This is because the entire ephrin-A5 molecule, including the GH^L loop, is tilted. (E) The EphA3/ephrin-A5 complex is oriented similarly to an EphA4/ephrin-A5 complex (PDBID 4M4R) that also shows a similar tilt of ephrin-A5 (Table 3). (F) The EphA3/ephrin-A5 complex is oriented similarly to the EphA4/ephrin-B2 complex (PDBID 2WO2).