Table 2. Significantly enriched pathways in Cluster-1.
| Pathway | p-value | FDR | Ratio |
|---|---|---|---|
| Cell cycle: Transition and termination of DNA replication | 3.074x10-4 | 1.687x10-2 | 3/28 |
| Development: Transcription factors in segregation of hepatocytic lineage | 3.784x10-4 | 1.687x10-2 | 3/30 |
| Cell cycle: Role of APC in cell cycle regulation | 4.593x10-4 | 1.687x10-2 | 3/32 |
| Signal transduction: Activin A signaling regulation | 5.035x10-4 | 1.687x10-2 | 3/33 |
| Cell cycle: The metaphase checkpoint | 6.524x10-4 | 1.748x10-2 | 3/36 |
| Immune response: T regulatory cell-mediated modulation of effector T cell and NK cell functions | 2.023x10-3 | 4.176x10-2 | 3/53 |
| Apoptosis and survival: Endoplasmic reticulum stress response pathway | 2.250x10-3 | 4.176x10-2 | 3/55 |
| Transcription: Epigenetic regulation of gene expression | 2.493x10-3 | 4.176x10-2 | 3/57 |
Significantly enriched pathways in Cluster-1 include the endoplasmic reticulum stress pathway which is highly associated with RAG transcripts. Pathways with a FDR adjusted p-value less than 0.05 were considered significant. The ratio is indicative of the number of pathway objects (denominator) included in Cluster-1 (numerator).