Table 3. Relevant HLA allele and block associations in SSc patients compared to healthy controls.
| HLA Block or allele | SSc (N = 316) | lcSSc (N = 188) | dcSSc (N = 128) | Controls (N = 468) | Comparissons, (pC value, Odds Ratio, 95% CI) | Association |
|---|---|---|---|---|---|---|
| n (g.f.) | n (g.f.) | n (g.f.) | n (g.f.) | |||
| C*07:02 | 43 (0.1360) | 33 (0.1750) | 10 (0.0780) | 97 (0.2070) | SSc vs Ctls (Yates pC = 0.01, OR = 0.60, 95%CI = 0.40–0.89), dcSSc vs Ctls (Yates pC = 0.001, OR = 0.32, 95%CI = 0.16–0.64), lcSSc vs Ctls (pC = ns), dcSSc vs lcSSc (Yates pC = 0.02, OR = 0.39, 95%CI = 0.18–0.84) | Protection to dcSSc |
| B*39:06 | 18 (0.0560) | 15 (0.0790) | 3 (0.0230) | 32 (0.0680) | SSc vs Ctls (pC = ns), dcSSc vs Ctls (pC = ns), lcSSc vs Ctls (pC = ns), dcSSC vs lcSSc (pC = ns) | |
| B*39:05 | 13 (0.0410) | 10 (0.0530) | 3 (0.0230) | 37 (0.0790) | SSc vs Ctls (pC = ns), dcSSc vs Ctls (Yates pC = 0.04, OR = 0.27, 95%CI = 0.08–0.92), lcSSc vs Ctls (pC = ns), dcSSC vs lcSSc (pC = ns) | |
| C*07:02-B*39:06 | 18 (0.0569) | 15 (0.0798) | 3 (0.0234) | 29 (0.0619) | SSc vs Ctls (pC = ns), dcSSc vs Ctls (pC = ns), lcSSc vs Ctls (pC = ns), dcSSC vs lcSSc (pC = ns) | |
| C*07:02-B*39:05 | 12 (0.0379) | 10 (0.0532) | 2 (0.0156) | 34 (0.0726) | SSc vs Ctls (pC = ns), dcSSc vs Ctls (Yates pC = 0.02, OR = 0.20, 95%CI = 0.04–0.85), lcSSc vs Ctls (pC = ns), dcSSC vs lcSSc (pC = ns) | |
| C*07:02-B*39:06 + C*07:02-B*39:05 | 30 (0.0949) | 25 (0.1329) | 5 (0.0390) | 63 (0.1346) | SSc vs Ctls (pC = ns), dcSSc vs Ctls (Yates pC = 0.004, OR = 0.26, 95%CI = 0.10–0.66), lcSSc vs Ctls (pC = ns), dcSSc vs lcSSc (Yates pC = 0.009, OR = 0.26, 95%CI = 0.09–0.71) | Protection to dcSSc |
| HLA Block or allele | ||||||
| C*07:01 | 23 (0.0720) | 11 (0.0580) | 12 (0.0930) | 25 (0.0530) | SSc vs Ctls (pC = ns), dcSSc vs Ctls (pC = ns), lcSSc vs Ctls (pC = ns), dcSSc vs lcSSc (pC = ns) | |
| B*08:01 | 14 (0.0440) | 8 (0.0420) | 6 (0.0460) | 3 (0.0060) | SSc vs Ctls (Yates pC = 0.0008, OR = 7.1, 95%CI = 2.04–25.21), dcSSc vs Ctls (Yates pC = 0.003, OR = 7.6, 95%CI = 1.88–30.92), lcSSc vs Ctls (Yates pC = 0.003, OR = 6.8; 95%CI = 1.8–26.25), dcSSc vs lcSSc (pC = ns) | Susceptibility to SSc |
| C*07:01-B*08:01 | 11 (0.0348) | 6 (0.0319) | 5 (0.0391) | 3 (0.0064) | SSc vs Ctls (Yates pC = 0.007, OR = 5.59, 95%CI = 1.54–20.20), dcSSc vs Ctls (Yates pC = 0.01, OR, 6.3, 95%CI = 1.48–26.73), lcSSc vs Ctls (Yates pC = 0.03, OR = 5.1, 95%CI = 1.26–20.65), dcSSc vs lcSSc (pC = ns) | Susceptibility to SSc |
| HLA Block or allele | ||||||
| C*12:03 | 18 (0.0560) | 7 (0.0370) | 9 (0.0700) | 12 (0.0250) | SSc vs Ctls (Yates pC = 0.04, OR = 2.29, 95% CI = 1.09–4.83), dcSSc vs Ctls (Yates pC = 0.03, OR = 2.87, 95%CI = 1.18–6.98), lcSSc vs Ctls (pC = ns), dcSSC vs lcSSc (pC = ns) | |
| B*18:01 | 12 (0.0370) | 5 (0.0260) | 7 (0.0540) | 8 (0.0170) | SSc vs Ctls (pC = ns), dcSSc vs Ctls (Yates pC = 0.03, OR = 3.32, 95%CI = 1.18–9.35), lcSSc vs Ctls (pC = ns), dcSSC vs lcSSc (pC = ns) | |
| C*12:03-B*18:01 | 7 (0.0198) | 1 (0.0053) | 6 (0.0469) | 2 (0.0042) | SSc vs Ctls (Yates pC = 0.04, OR = 5.27, 95%CI = 1.08–25.57), dcSSc vs Ctls (Yates pC = 0.001, OR = 11.46, 95%CI = 2.28–57.48), lcSSc vs Ctls (pC = ns), dcSSC vs lcSSc (Yates pC = 0.03, OR = 9.1, 95%CI = 1.09–77.32) | Susceptibility to dcSSc |
| HLA Block or allele | ||||||
| DRB1*11:04 | 13 (0.0410) | 3 (0.0150) | 10 (0.0780) | 8 (0.0170) | SSc vs Ctls (pC = ns), dcSSc vs Ctls (Yates pC = 0.001, OR = 4.87, 95%CI = 1.88–12.02), lcSSc vs Ctls (pC = ns), dcSSC vs lcSSc (Yates pC = 0.01, OR = 5.22, 95%CI = 1.40–19.38) | Susceptibility to SSc |
| DQB1*03:01 | 46 (0.1450) | 24 (0.1270) | 22 (0.1710) | 116 (0.2470) | SSc vs Ctls (Yates pC = 0.0007, OR = 0.51, 95%CI = 0.35–0.75), dcSSc vs Ctls (pC = ns), lcSSc vs Ctls (Yates pC = 0.0009, OR = 0.44, 95%CI = 0.27–0.71), dcSSC vs lcSSc (pC = ns) | Protection to SSc (lcSSc) |
| DRB1*11:04-DQB1*03:01 | 11 (0.0348) | 2 (0.0106) | 9 (0.0703) | 8 (0.0171) | SSc vs Ctls (pC = ns), dcSSc vs Ctls (Yates pC = 0.001, OR = 4.87, 95%CI = 1.64–11.51), lcSSc vs Ctls (pC = ns), dcSSC vs lcSSc (Yates pC = 0.01, OR = 7.03, 95%CI = 1.49–33.10) | Susceptibility to SSc |
| HLA Block or allele | ||||||
| DRB1*01:02 | 16 (0.0500) | 11 (0.0580) | 5 (0.0390) | 11 (0.0230) | SSc vs Ctls (pC = ns), dcSSc vs Ctls (pC = ns), lcSSc vs Ctls (pC = 0.04, OR = 2.58, 95%CI = 1.1–6.06), dcSSc vs lcSSc (pC = ns) | |
| DRB1*0101 | 12 (0.0370) | 10 (0.0530) | 2 (0.0150) | 9 (0.0190) | SSc vs Ctls (pC = ns), dcSSc vs Ctls (pC = ns), lcSSc vs Ctls (Yates pC = 0.03, OR = 2.8; 95%CI = 1.1–7.1), dcSSC vs lcSSc (pC = ns) | |
| DQB1*05:01 | 32 ((0.1010) | 21 (0.1110) | 11 (0.0850) | 32 (0.0680) | SSc vs Ctls (pC = ns), dcSSc vs Ctls (pC = ns), lcSSc vs Ctls (pC = ns), dcSSc vs lcSSc (pC = ns) | |
| DRB1*01:02-DQB1*05:01+DRB1*01:01-DQB1*0501 | 28 (0.0800) | 21 (0.1117) | 7 (0.0546) | 20 (0.0427) | SSc vs Ctls (Yates pC = 0.01, OR = 2.1, 95%CI = 1.20–3.93), dcSSc vs Ctls (pC = ns), lcSSc vs Ctls (Yates pC = 0.001, OR = 2.80, 95%CI = 1.48–5.32), dcSSc vs lcSSc (pC = ns) | Susceptibiity to SSc |
| HLA Block or allele | ||||||
| DRB1*04:04 | 17 (0.053) | 15 (0.079) | 2 (0.015) | 31 (0.066) | SSc vs Ctls (pC = ns), dcSSc vs Ctls (Yates pC = 0.04, OR = 0.2, 95%CI = 0.05–0.94), lcSSc vs Ctls (pC = ns), dcSSC vs lcSSc (Yates pC = 0.02, OR = 0.18, 95%CI = 0.04–0.81) | |
| DQB1*03:02 | 84 (0.26) | 57 (0.303) | 27 (0.21) | 115 (0.245) | SSc vs Ctls (pC = ns), dcSSc vs Ctls (pC = ns), lcSSc vs Ctls (pC = ns), dcSSC vs lcSSc (pC = ns) | |
| DRB1*04:04/DQB1*03:02 | 17 (0.053) | 15 (0.079) | 2 (0.015) | 29 (0.062) | SSc vs Ctls (pC = ns), dcSSc vs Ctls (pC = ns), lcSSc vs Ctls (pC = ns), dcSSC vs lcSSc (Yates pC = 0.02, OR = 0.1, 95%CI = 0.01–0.8) | |
| HLA Block or allele | ||||||
| DRB1*14:06 | 13 (0.0410) | 8 (0.0420) | 5 (0.0390) | 47 (0.1000) | SSc vs Ctls (Yates pC = 0.002, OR = 0.30, 95%CI = 0.20–0.72), dcSSc vs Ctls (Yates pC = 0.04, OR = 0.36, 95%CI = 0.14–0.93), lcSSc vs Ctls (Yates pC = 0.02, OR = 0.39, 95%CI = 0.18–0.85), dcSSC vs lcSSc (pC = ns) | Protection to SSc |
| DRB1*16:02 | 7 (0.0220) | 4 (0.0210) | 3 (0.0230) | 30 (0.0640) | SSc vs Ctls (Yates pC = 0.01, OR = 0.33, 95%CI = 0.14–0.70), dcSSc vs Ctls (pC = ns), lcSSc vs Ctls (Yates pC = 0.04, OR = 0.31, 95%CI = 0.11–0.91), dcSSC vs lcSSc (pC = ns) | |
| DRB1*14:02 | nd | nd | nd | 11 (0.0235) | SSc vs Ctls (Yates pC = 0.03, OR = 0.12, 95%CI = 0.01–0.93), dcSSc vs Ctls (pC = 0.3), lcSSc vs Ctls (pC = ns), dcSSC vs lcSSc (pC = ns) | |
| DQB1*03:01 | 46 (0.1450) | 24 (0.1270) | 22 (0.1710) | 116 (0.2470) | SSc vs Ctls (Yates pC = 0.0007, OR = 0.51, 95%CI = 0.35–0.75), dcSSc vs Ctls (pC = ns), lcSSc vs Ctls (Yates pC = 0.0009, OR = 0.44, 95%CI = 0.27–0.71), dcSSC vs lcSSc (pC = ns) | Protection to SSc (lcSSc) |
| DRB1*1406-DQB1*0301 | 12 (0.0380) | 8 (0.0426) | 4 (0.0313) | 46 (0.0983) | SSc vs Ctls (Yates pC = 0.002, OR = 0.36, 95%CI = 0.18–0.69), dcSSc vs Ctls (Yates pC = 0.02, OR = 0.29, 95%CI = 0.10–0.83), lcSSc vs Ctls (Yates pC = 0.02, OR = 0.40, 95%CI = 0.18–0.88), dcSSC vs lcSSc (pC = ns) | Protection to SSc |
| DRB1*16:02-DQB1*0301 | 7 (0.0222) | 4 (0.0213) | 3 (0.0234) | 30 (0.0641) | SSc vs Ctls (Yates pC = 0.01, OR = 0.33, 95%CI = 0.14–0.76), dcSSc vs Ctls (pC = ns), lcSSc vs Ctls (Yates pC = 0.04, OR = 0.3; 95%CI = 0.1–0.9), dcSSC vs lcSSc (pC = ns) | Protection to SSc |
| DRB1*14:02-DQB1*03:01 | nd | nd | nd | 11 (0.0235) | SSc vs Ctls (Yates pC = 0.03, OR = 0.12, 95%CI = 0.01–0.93), dcSSc vs Ctls (pC = 0.3), lcSSc vs Ctls (pC = ns), dcSSC vs lcSSc (pC = ns) | Protection to SSc |
| DRB1*1406-DQB1*0301 + DRB1*16:02-DQB1*0301 +DRB1*14:02-DQB1*03:01 | 19 (0.0601) | 12 (0.0638) | 7 (0.0546) | 87 (0.1858) | SSc vs Ctls (Yates pC = 0.000001, OR = 0.28, 95%CI = 0.16–0.47), dcSSc vs Ctls (Yates pC = 0.005, OR = 0.25, 95%CI = 0.11–0.56), lcSSc vs Ctls (Yates pC = 0.0001, OR = 0.29, 95%CI = 0.15–0.56), dcSSC vs lcSSc (pC = ns) | Protection to SSc |
SSc: Systemic sclerosis patients, dcSSc: diffuse cutaneous systemic sclerosis, lcSSc: limited cutaneous systemic sclerosis, pC: p corrected value, OR: odds ratio, 95% CI: 95% confidence interval, ns: non-significant, nd: not detected.