Fig 1. Schematic of the model neuronal circuitry involved in responses to methamphetamine.

Stress input and the orexin receptors (shown by gray rectangles labeled “OX”) are added to extend the circuitry used in [30]. Effect of Stress and/or Meth can be affected by the orexin receptor antagonist SB-334867. Each circle represents a neural population. Abbreviations: Exc—excitatory node, Inhib—inhibitory node, HD—high-dose activated node, Med—medullary node, SPN—sympathetic preganglionic node, TEMP—temperature. See text for a detailed description.