Table 1.
Baseline characteristics of Type 1 diabetics in included studies
| Characteristic | DIRECT | EUCLID | RASS | Chase | |
|---|---|---|---|---|---|
| Prevent-1 | Protect-1 | ||||
| Number enrolled | 1421 | 1905 | 530 | 285 | 16 |
| Number analyzed | 1421 | 1905 | 354 | 223 | 16 |
| Age, years (mean) | 30 | 32 | 34 | 30 | 21 |
| Men, %1 | 57 | 58 | 65 | 47 | 75 |
| White, %1 | 97 | 98 | - | 98 | - |
| Diabetes duration, years (mean) | 6.7 | 11.0 | 14.5 | 11.2 | 12.9 |
| Current smoker, %1 | 26 | 26 | 30 | - | - |
| Systolic blood pressure (mean) | 116 | 117 | 123 | 120 | 115 |
| Diastolic blood pressure (mean) | 72 | 74 | 81 | 70 | 78 |
| Body-mass index (kg/m2; mean) | 24.0 | 24.6 | 24.7 | 25.7 | - |
| HbA1c (mean) | 8.1 | 8.5 | 7.1 | 8.5 | 8.4 |
| Retinopathy, worse eye, %2 | |||||
| Number of participants with gradeable baseline photographs | 1421 | 1905 | 354 | 223 | 16 |
| ETDRS ≤ 20: None or microaneurysms only | 100 | 49 | 38 | 34 | 44 |
| ETDRS 31 to 37: Mild non-proliferative | 0 | 42 | 41 | 56 | 25 |
| ETDRS 41 to 53: Moderate or severe non-proliferative | 0 | 9 | 12 | 9 | 25 |
| ETDRS > 53: Proliferative or panretinal photocoagulation | 0 | 0 | 8 | 0 | 6 |
1
Percentages based on number of participants enrolled.
2
Percentages based on number of participants with gradeable photographs.
- Indicates no data were available in the study publications found.
Data shown for RASS includes the number of participants analyzed for retinopathy outcomes.