Table 1.

Pharmacokinetic parameters of IFLs

	Cmaxa	rb	tmaxc	t1/2d	C24e	C36f	C48g
	(μM)		(hours)	(hours)	(rel. to Cmax) (%)	(rel. to Cmax) (%)	(rel. to Cmax) (%)
DE	1.97 ± 0.63	0.93	6.2 ± 1.5	7.7 ± 3.3	20	7	2
GE	2.37 ± 0.41	0.71	5.7 ± 1.8	9.5 ± 3.2	26	11	5
D*	3.46 ± 0.75	0.85	7.5 ± 1.6	7.0 ± 1.6	20	6	2
G*	3.78 ± 1.00	0.85	6.8 ± 1.4	9.5 ± 1.7	29	12	5

^aPeak plasma levels in μM per mg IFL per kg BW.

^bcorrelation between dose and plasma levels by linear regression.

^ctime to reach peak plasma levels.

^dtime to reach peak plasma levels.

^a–dmean of 16 studies.^[59]

^e% plasma level after 24 hours relative to peak plasma levels.

^f% plasma level after 36 hours relative to peak plasma levels.

^g% plasma level after 48 hours relative to peak plasma levels.

^*When dosed in aglycon units.