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. Author manuscript; available in PMC: 2016 Jun 30.
Published in final edited form as: Psychiatry Res. 2015 Mar 31;232(3):226–236. doi: 10.1016/j.pscychresns.2015.03.006

FIGURE 2. Stress Response Circuitry Deficits in Psychoses in Male (A) and Female (B) Cases versus Healthy Controls.

FIGURE 2

A and B: Activations of hypothesized regions of interest were derived using the small volume correction tool in SPM8, restricted to anatomical borders defined by a manually segmented MNI brain. Peak voxel activations were significant at p<.05, FWE-corrected.

A) Male psychosis cases (PSY) showed significant hyperactivity compared to male controls in right hypothalamus (HYPO) and anterior cingulate cortex (ACC), and hypoactivity in left hypothalamus (HYPO).

B) Female cases showed hyperactivity in subcortical arousal regions, and hypoactivity in medial prefrontal cortex (mPFC) by FWE-correction and orbitofrontal cortex (not shown here, given trend-level significance).