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. Author manuscript; available in PMC: 2016 Jun 30.
Published in final edited form as: Psychiatry Res. 2015 Mar 31;232(3):226–236. doi: 10.1016/j.pscychresns.2015.03.006

Figure 3. Interaction of Case Status by Sex on BOLD signal intensity changes in Prefrontal Cortices (A) medial prefrontal cortex and (B) left orbital frontal cortex.

Figure 3

Interaction of sex by group on BOLD signal changes (negative > neutral stimuli) in response to stress were tested using mixed linear models (SAS 9.3, 2002–2010). Average percent BOLD-signal change (PSC) within an ROI was extracted for each subjects using ROI-extraction (REX) toolbox for SPM8 (Whitfield-Gabrieli, 2009). This value represents the average of PSC values across all voxels within an anatomical ROI. Interactions are illustrated (above) by sex-specific lines connecting mean PSC for cases and controls (mPFC: Females, Case (0.12) < Control (0.91); Males, Case (1.04) > Control (0.45). L_OFC: Females, Case (0.06) < Control (0.48); Males, Case (0.59) > Control (0.31). (a) mPFC (interaction: β = 0.13, P = 0.01), and (b) L_OFC (interaction: β = 0.07, P = 0.09).