Table 2.

Regions of activation comparing negative to neutral stimuli in healthy control and participants with psychoses: within sex by group contrasts

Contrast		Men (n=38)								Women (n=32)
Region of interest (ROI)		x	y	z a	voxel	Z	p-valueb	FWE-corrected p-valuec	dd	x	y	z a	voxel	Z	p-valueb	FWE-corrected p-valuec	dd
PSY > HC
L	Amygdala									−30	−7	−23	1	1.73	0.042	0.134	0.45
R										27	−4	−20	1	1.71	0.044	0.139	0.37
R	Hypothalamus	6	14	−5	4	2.3	0.011	0.045	0.73
L	Anterior hippocampus									−33	−19	−17	5	1.95	0.025	0.09	0.44
R	Parahippocampal gyrus	15	−37	−2	3	2.12	0.017	0.068	0.45
L	Anterior cingulate cortex	−6	47	19	18	3.08	0.001	0.026	0.29
L	Orbital frontal cortex	−42	32	−14	6	2.05	0.02	0.213	0.39
R		33	26	−20	13	2.1	0.018	0.198	0.50
	Medial prefrontal cortex	−3	56	−8	12	2.05	0.02	0.212	0.51
	Periaqueductal gray	0	−31	−8	1	1.73	0.042	0.137	0.40
HC > PSY
L	Hypothalamus	−6	−7	−5	8	2.48	0.007	0.031	−0.73
L	Orbital frontal cortex									−45	26	−14	2	1.84	0.033	0.272	−0.44
	Medial prefrontal cortex									−6	53	−14	44	2.91	0.002	0.038	−0.79

^aCoordinates are presented in Montreal Neurologic Institute space.

^bVoxel-wise Z-score significance level p<0.05 uncorrected for multiple comparisons within a hypothesized region of interest; ROIs listed represent regions of significantly activated clusters within the a priori hypothesized ROI.

^cFWE rate (family-wise error rate) used for small volume correction: voxel-level significance level (FWE-corrected within the search volume of interest).

^dEffect sizes (d=Cohen’s d) based on average percent signal change values (beta weights averaged across an anatomical ROI) were obtained using the REX toolbox for Statistical Parametric Mapping-8.