Table 1.

Median values of biomarkers in cases and controls at study entry

Biomarkers, median(range)	Deaths(n=142)	Controls (n=284)	p-value*
Innate/pro-inflammatory response
IL-6, pg/ml	3.64 (0.39, 104.8)	2.26 (0.41, 12.05)	<.001
TNF-alfa, pg/ml	12.68 (1.99, 147.8)	11.80 (1.89, 64.48)	0.009
IL-1 beta, pg/ml	0.61 (0.02, 15.02)	0.63 (0.02, 24.40)	0.352
Cell trafficking
CXCL8, pg/ml	6.84 (0.93, 68.71)	5.25 (0.40, 355.4)	0.008
CXCL10, pg/ml	348.4 (50.26, 5903)	288.0 (21.63, 8171)	0.068
Cell activation/proliferation
IL-2, pg/ml	2.81 (0.07, 90.16)	3.32 (0.06, 104.1)	0.848
IL-7, pg/ml	9.86 (0.17, 144.3)	11.11 (0.17, 111.9)	0.649
IL-17, pg/ml	2.98 (0.07, 115.2)	3.03 (0.07, 200.2)	0.448
IFN-gamma, pg/ml	4.82 (0.06, 89.19)	5.39 (0.07, 195.1)	0.614
GMCSF, pg/ml	0.86 (0.03, 76.52)	0.83 (0.05, 112.7)	0.150
IL-4, pg/ml	21.67 (0.01, 1260)	26.04 (0.00, 2354)	0.184
IL-5, pg/ml	0.55 (0.01, 9.87)	0.55 (0.01, 26.23)	0.695
IL-13, pg/ml	1.40 (0.01, 624.0)	3.92 (0.01, 1073)	0.383
IL-10, pg/ml	25.38 (0.18, 1215)	25.00 (0.18, 414.3)	0.359
IL-12p70, pg/ml	2.01 (0.04, 732.9)	2.51 (0.01, 308.1)	0.802

^*from fitting a conditional logistic regression (markers in log scale). Only patients with observed values included