Figure 2.
Biglycan and decorin compensate for each other in fetal membranes in the absence of inflammation, but not in the presence of inflammation. [A] Biglycan gene expression is increased in the PBS injected decorin null fetal membranes compared to wild-type (p=0.02); this compensatory increase does not occur in the setting of inflammation [B] Decorin gene expression is increased in the PBS-injected biglycan null fetal membranes compared to wild-type (p=0.006); this compensatory increase does not occur in the setting of inflammation, but decreased decorin gene expression occurs in the E. coli injected biglycan null fetal membranes compared to the PBS injected biglycan null fetal membranes (p=0.009). n=4 per genotype and condition. Error bars = SD. BgnKO=biglycan null; DcnKO=decorin null; WT=wild-type; PBS=phosphate buffered saline. Student’s t-test was performed for each set of data.