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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: J Hepatol. 2015 Feb 7;62(6):1367–1374. doi: 10.1016/j.jhep.2015.01.032

Fig. 4. Time course of JNK activation and effect of Sab knockdown, JNKi, and antioxidant.

Fig. 4

(A) Knockdown of Sab did not affect JNK activation at 1 and 4 hours but decreased P-JNK at 8 hours. (B) JNK inhibitor as expected decreased palmitic acid induced sustained JNK activation. (C) Time course of JNK translocation to mitochondria following palmitic acid treatment. The graph represents P-JNK densitometry normalized to OTC. (D) Time course of JNK activation in whole cell lysate from same experiments as C. The graphs represent P-JNK densitometry normalized to JNK. N=3 experiment (E) Time course of cell death in shlacZ vs shSab. N=3 experiments,*P<0.05.