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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Autoimmunity. 2014 Nov 20;48(4):222–230. doi: 10.3109/08916934.2014.984836

Figure 5.

Figure 5

Acthar reduces the numbers of activated microglia/macrophages in the spinal cords of EAE mice. (A) Representative spinal cord tissue sections stained for RCA-1, as described in the “Methods” section. Images shown at 20× magnification and insets at 10× magnification. (B) Enumeration of RCA-1+ cells from spinal cord tissue sections obtained from mice in which treatment was initiated at the onset of relapse (n = 15 for no treatment, 12 for Acthar treatment and 8 for Placebo gel treatment). **p<0.01, ANOVA followed by Dunn’s test. (C) Enumeration of RCA-1+ cells from spinal cord tissue sections obtained from mice in which treatment was initiated after the onset of relapse (n = 16 for all groups of mice). **p<0.01, ANOVA followed by Tukey’s test. Values represent the mean ± SEM (at least six spinal cord tissue sections were scored for each mouse). NT no treatment.