Table 1.
Characteristics and ETC Activities of PD and Control Subjects
| Variable | PD Patients (N=23) | Controls (N=23) | p-value* |
|---|---|---|---|
| Demographics | |||
| Age (mean ± SD) | 70.5 (11.8) | 71.0 (9.9) | 0.88 |
| Duration of PD (mean ± SD) | 2.09 (1.2) | - | - |
| Female (%) | 56.5 | 52.2 | 0.76 |
| Never Smokers (%) | 34.8 | 47.8 | 0.47 |
| Non-Caucasian (%) | 17.4 | 13 | - |
| Health Indicators | |||
| UPDRS motor score (mean ± SD) | 19.4 (8.4) | - | - |
| MMSE score (mean ± SD) | 27.0 (4.1) | 28.9 (1.1) | 0.03 |
| Mitochondrial Function: | |||
| Complex I (CI) (mean ± SD) | 16.6 (12.6) | 14.3 (8.1) | 0.37 |
| Citrate synthase (CS) (mean ± SD) | 410.5 (216.0) | 361.8 (160.6) | 0.39 |
| CI/CS (mean ± SD) | 0.044 (0.02) | 0.040 (0.01) | 0.46 |
| NCCR (mean ± SD)† | 34.4 (23.2) | 29.5 (20.6) | 0.46 |
| NCCR/CS (mean ± SD)† | 0.078 (0.03) | 0.076 (0.03) | 0.82 |
*
P-value based on ttest or chi-square, PD patients vs Controls; not calculated in some instances due to small numbers.
†
1 additional PD case and 1 control failed NCCR experiment (n=44)