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[A] Effective arterial elastance (Ea) was reduced at rest after 24 weeks treatment in subjects randomized to sildenafil (red) compared to placebo. [B] 24 week changes in endothelial function, assessed as the reactive hyperemia index (RHI) in placebo and sildenafil. Left ventricular contractility, assessed as [C] peak power index (PWR/EDV) and [D] stroke work index (SW/EDV) was reduced after 24 weeks treatment with sildenafil (red) as compared to placebo (black).
