Table 1.

Regional distribution volume (V_T) for [¹¹C]Martinostat baseline binding (n=4, 90 min scan) were estimated with one- and two-tissue compartmental models (1TCM and 2TCM) and graphical analysis (Logan Plot and MA1). Goodness of fit for one- and two-tissue compartmental models (1TCM and 2TCM) is evaluated with Akaike information criteria (AIC) and Model selection criteria (MSC).

	VT (mL/cm3)				AIC		MSC
Brain Region	1TCM	2TCM	Logan	MA1	1TCM	2TCM	1TCM	2TCM
ACC	20 ± 4	32 ± 9	38 ± 13	43 ± 10	75 ± 9	23 ± 6	0.4 ± 0.5	2.6 ± 0.5
Amygdala	22 ± 4	42 ± 6	37 ± 12	49 ± 10	69 ± 12	23 ± 16	1 ± 0.7	2.9 ± 0.8
Cerebellum	30 ± 10	54 ± 16	59 ± 17	75 ± 25	73 ± 11	20 ± 26	0.8 ± 0.6	3 ± 1.2
DLPFC	26 ± 5	42 ± 10	44 ± 12	50 ± 6	62 ± 9	10 ± 15	1.4 ± 0.5	3.5 ± 0.5
Hippocampus	21 ± 4	37 ± 8	36 ± 16	51 ± 11	72 ± 7	37 ± 17	0.9 ± 0.4	2.3 ± 0.6
M1	25 ± 5	45 ± 10	46 ± 13	60 ± 6	65 ± 10	7 ± 14	1.2 ± 0.5	3.6 ± 0.6
NAc	19 ± 5	33 ± 13	36 ± 13	42 ± 13	76 ± 9	26 ± 24	0.5 ± 0.6	2.6 ± 1.2
OFC	19 ± 6	34 ± 17	35 ± 23	41 ± 24	72 ± 7	32 ± 16	0.8 ± 0.3	2.5 ± 0.7
PCC	19 ± 4	33 ± 5	36 ± 7	41 ± 8	72 ± 8	21 ± 20	0.7 ± 0.6	2.8 ± 1
Putamen	29 ± 7	50 ± 14	55 ± 15	63 ± 20	68 ± 8	15 ± 14	1.1 ± 0.3	3.3 ± 0.6
SMA	25 ± 5	41 ± 9	40 ± 14	46 ± 10	73 ± 10	19 ± 19	0.7 ± 0.7	2.9 ± 0.9
Thalamus	24 ± 6	40 ± 8	40 ± 12	45 ± 12	68 ± 13	15 ± 14	1.1 ± 0.7	3.3 ± 0.7
V1	22 ± 6	37 ± 10	39 ± 15	45 ± 12	81 ± 9	36 ± 21	0.3 ± 0.6	2.2 ± 0.9
Caudate	26 ± 6	44 ± 10	42 ± 17	54 ± 10	67 ± 6	8 ± 14	1.1 ± 0.4	3.6 ± 0.7
WM	17 ± 4	30 ± 8	33 ± 7	36 ± 8	63 ± 8	5 ± 20	1.2 ± 0.5	3.6 ± 0.8

ACC: anterior cingulate cortex, DLPFC: dorsal lateral prefrontal cortex, M1: primary motor cortex, NAc: nucleus accumbens, OFC: orbitofrontal cortex, PCC: posterior cingulate cortex, SMA: supplementary motor area, V1: primary visual cortex, WM: white matter.