Table 2.

Kinetic rate constants estimated from four baseline [¹¹C]Martinostat scans (n=4) with a two-tissue compartmental model.

Brain Region	K1 (mL/cm3/min)	%COV	k2 (1/min)	%COV	k3 (1/min)	%COV	k4 (1/min)	%COV
ACC	0.78 ± 0.25	11 ± 5	1.5 ± 1.25	23 ± 5	0.4 ± 0.15	14 ± 3	0.0089 ± 0.0037	18 ± 4
Amygdala	0.53 ± 0.2	9 ± 4	0.6 ± 0.41	25 ± 9	0.3 ± 0.1	17 ± 4	0.0071 ± 0.003	27 ± 9
Cerebellum	0.83 ± 0.22	10 ± 6	0.87 ± 0.77	26 ± 11	0.34 ± 0.23	19 ± 12	0.008 ± 0.003	25 ± 14
DLPFC	0.6 ± 0.17	8 ± 5	0.63 ± 0.48	23 ± 9	0.34 ± 0.21	16 ± 7	0.0099 ± 0.0037	17 ± 4
Hippocampus	0.56 ± 0.16	17 ± 14	1.03 ± 1.07	38 ± 19	0.39 ± 0.23	22 ± 7	0.0078 ± 0.0035	31 ± 14
M1	0.59 ± 0.21	7 ± 3	0.6 ± 0.41	19 ± 4	0.3 ± 0.19	14 ± 5	0.0081 ± 0.0026	18 ± 4
NAc	0.67 ± 0.19	11 ± 6	1.08 ± 0.81	24 ± 8	0.35 ± 0.17	15 ± 5	0.0087 ± 0.003	20 ± 5
OFC	0.52 ± 0.15	11 ± 6	0.76 ± 0.64	30 ± 10	0.3 ± 0.18	22 ± 11	0.0085 ± 0.0032	27 ± 7
PCC	0.57 ± 0.22	9 ± 3	0.75 ± 0.46	22 ± 5	0.32 ± 0.16	15 ± 4	0.0084 ± 0.003	21 ± 7
Putamen	0.74 ± 0.12	9 ± 5	0.88 ± 0.84	23 ± 8	0.35 ± 0.2	16 ± 8	0.0084 ± 0.0033	18 ± 4
SMA	0.84 ± 0.33	12 ± 8	1.07 ± 0.73	24 ± 11	0.37 ± 0.19	15 ± 6	0.0086 ± 0.003	19 ± 6
Thalamus	0.63 ± 0.24	8 ± 3	0.68 ± 0.44	23 ± 10	0.33 ± 0.13	16 ± 7	0.0089 ± 0.0036	18 ± 4
V1	0.89 ± 0.2	12 ± 7	1.01 ± 0.79	26 ± 10	0.32 ± 0.17	17 ± 5	0.0092 ± 0.0031	24 ± 11
Caudate	0.66 ± 0.18	7 ± 3	0.73 ± 0.47	19 ± 6	0.35 ± 0.15	13 ± 4	0.0084 ± 0.0028	16 ± 4
WM	0.39 ± 0.13	7 ± 4	0.52 ± 0.35	19 ± 8	0.29 ± 0.18	14 ± 4	0.0087 ± 0.003	17 ± 5
Average	0.65		0.85		0.34		0.0085