Table 2.
Univariable analysis comparing various degrees of surgical resection in children with renal cell carcinoma. y = years, IQR = interquartile range.
| Variable | No Surgery | Partial Nephrectomy | Complete Nephrectomy | P value |
|---|---|---|---|---|
| N (%) | 39 (14) | 40 (14) | 204 (72) | |
| Age, y | 0.52 | |||
| <5 | 3 (8%) | 2 (5%) | 16 (8%) | |
| 5–8 | 6 (15%) | 5 (12.5%) | 28 (14%) | |
| 9–13 | 16 (41%) | 9 (22.5%) | 68 (33%) | |
| >13 | 14 (36%) | 24 (60%) | 92 (45%) | |
| Female | 14 (36%) | 24 (60%) | 94 (46) | 0.10 |
| Race/ethnicity | 0.11 | |||
| White | 14 (36%) | 27 (68%) | 114 (57%) | |
| Black | 18 (46%) | 8 (20%) | 66 (33%) | |
| Other | 7 (18%) | 5 (12%) | 20 (10%) | |
| Median tumor size, cm (IQR) | 3 (2, 7) | 3 (2, 5) | 6 (4, 9) | <0.001 |
| Tumor size | 0.001 | |||
| ≤4 cm | 12 (52%) | 25 (66%) | 60 (30%) | |
| 4.1–7 cm | 5 (22%) | 9 (24%) | 58 (29%) | |
| 7.1–10 cm | 3 (13%) | 3 (8%) | 44 (22%) | |
| >10 cm | 3 (13%) | 1 (3%) | 38 (19%) | |
| Clinical staging group | <0.001 | |||
| I | 7 (26%) | 20 (91%) | 45 (43%) | |
| II | 0 (0%) | 1 (4.5%) | 26 (25%) | |
| III | 0 (0%) | 1 (4.5%) | 20 (19%) | |
| IV | 20 (74%) | 0 (0%) | 13 (13%) | |
| Surgical margins | 0.08 | |||
| Negative | N/A | 36 (97%) | 182 (93%) | |
| Positive | N/A | 1 (3%) | 14 (7%) | |
| Chemotherapy | 20 (50%) | 2 (5%) | 31 (16%) | <0.001 |
| Radiation therapy | 6 (15%) | 0 (0%) | 6 (3%) | 0.003 |