Table 4. Odds ratios (OR) and 95% confidence intervals (CI) of migraine status according to serum lipid/lipoproteins and pre-pregnancy obesity status.
| Elevated biomarker level & Pre-pregnancy Obesity | No Migraine (N = 866) n (%) |
Yes Migraine (N = 196) n (%) |
Unadjusted OR (95%CI) |
Adjusted OR (95%CI) |
|---|---|---|---|---|
| Total cholesterol | ||||
| No & No | 577 (66.6) | 103 (52.6) | 1.00 (REF) | 1.00 (REF) |
| Yes & No | 206 (23.8) | 63 (32.1) | 1.71 (1.21- 43) | 1.70 (1.20-2.42) |
| No & Yes | 69 (8.0) | 20 (10.2) | 1.62 (0.95-2.79) | 1.52 (0.88-2.63) |
| Yes & Yes | 14 (1.6) | 10 (5.1) | 4.00 (1.73-9.25) | 3.71 (1.58-8.71) |
| P value for interaction term | 0.483 | 0.493 | ||
| HDL cholesterol | ||||
| Yes & No | 596 (68.8) | 130 (66.3) | 1.00 (REF) | 1.00 (REF) |
| No & No | 187 (21.6) | 36 (18.4) | 0.88 (0.59-1.32) | 0.86 (0.57-1.30) |
| Yes & Yes | 61 (7.0) | 21 (10.7) | 1.58 (0.93-2.68) | 1.46 (0.85-2.50) |
| No & Yes | 22 (2.5) | 9 (4.6) | 1.88 (0.84-4.17) | 1.75 (0.78-3.94) |
| P value for interaction term | 0.562 | 0.519 | ||
| LDL cholesterol | ||||
| No & No | 583 (67.3) | 112 (57.1) | 1.00 (REF) | 1.00 (REF) |
| Yes & No | 200 (23.1) | 54 (27.5) | 1.41 (0.98-2.02) | 1.39 (0.96-2.00) |
| No & Yes | 65 (7.5) | 20 (10.2) | 1.60 (0.93-2.75) | 1.49 (0.86-2.57) |
| Yes & Yes | 18 (2.1) | 10 (5.1) | 2.89 (1.30-6.43) | 2.71 (1.21-6.10) |
| P value for interaction term | 0.620 | 0.592 | ||
| Triglyceride | ||||
| No & No | 592 (68.4) | 110 (56.1) | 1.00 (REF) | 1.00 (REF) |
| Yes & No | 191 (22.1) | 56 (28.6) | 1.58 (1.10-2.26) | 1.57 (1.09-2.26) |
| No & Yes | 56 (6.5) | 17 (8.7) | 1.63 (0.92-2.92) | 1.56 (0.87-2.81) |
| Yes & Yes | 27 (3.1) | 13 (6.6) | 2.59 (1.30-5.18) | 2.36 (1.17-4.79) |
| P value for interaction term | 0.991 | 0.939 | ||
| Total cholesterol:HDL ratio | ||||
| No & No | 194 (22.4) | 28 (14.3) | 1.00 (REF) | 1.00 (REF) |
| Yes & No | 589 (68.0) | 138 (70.4) | 1.62 (1.05-2.51) | 1.58 (1.02-2.46) |
| No & Yes | 20 (2.3) | 4 (2.0) | 1.39 (0.44-4.35) | 1.32 (0.42-4.19) |
| Yes & Yes | 63 (7.3) | 26 (13.3) | 2.86 (1.56-5.23) | 2.62 (1.41-4.88) |
| P value for interaction term | 0.706 | 0.727 |
Adjusted for maternal age and parity. Separate models were fitted for each lipid or lipoprotein
Definition: High total cholesterol: ≥282 mg/dL (Q4); low total cholesterol: <282 mg/dL (Q1-Q3);
Low HDL cholesterol: <56mg/dL (Q1); high HDL cholesterol: ≥56 mg/dL (Q2-Q4);
High LDL cholesterol: ≥170 mg/dL (Q4); low LDL cholesterol: <170 mg/dL (Q1-Q3);
High triglyceride: ≥253 mg/dL (Q4); low triglyceride: <253 mg/dL (Q1-Q3);
High total cholesterol:HDL ratio: ≥3.4 (Q2-Q4); low total cholesterol:HDL ratio: <3.4 (Q1).