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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Anesthesiology. 2015 Jun;122(6):1401–1413. doi: 10.1097/ALN.0000000000000619

Figure 2.

Figure 2

Pharmacological activation of adenosine monophosphate-activated protein kinase (AMPK) in the spinal cord attenuated preexisting thermal hyperalgesia induced by partial sciatic nerve ligation (pSNL). Line plots show measurements of the hind paw withdrawal response latency (± SEM) to thermal stimuli collected at baseline (BL, day 0), 10 days postsurgery (10 DPS), and then 15, 30, 60, 90, 180 min, and 24 h after the intrathecal administration of the tested agent. Baseline (day 0) indicates the baseline measurement before animals received surgery. Comparisons between data collected on 10 DPS and at each time point are indicated with a + for the pSNL + AMPK Activator group. Comparisons between the pSNL + Vehicle group and the pSNL + AMPK Activator group are labeled with #. One symbol: p < 0.05, Two symbols: p < 0.01.